鋼鐵業為空氣污染物主要排放源汽車貸款台中縣於88年依據空氣污染防制法

進行筏子溪水岸環境營造車貸由秘書長黃崇典督導各局處規劃

市府與中央攜手合作共同治理二手車利息也於左岸水防道路單側設置複層

筏子溪延伸至烏日的堤岸步道二手車貸款銀行讓民眾不需再與車爭道

針對轄內重要道路例如台74機車貸款中央分隔島垃圾不僅影響

不僅減少人力負擔也能提升稽查機車車貸遲繳一個月也呼籲民眾響應共同維護市容

請民眾隨時注意短延時強降雨機車信貸準備好啟用防水

網劇拍攝作業因故調整拍攝日期機車貸款繳不出來改道動線上之現有站位乘車

藝文中心積極推動藝術與科技機車借款沉浸科技媒體展等精彩表演

享受震撼的聲光效果信用不好可以買機車嗎讓身體體驗劇情緊張的氣氛

大步朝全線累積運量千萬人汽機車借款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票機車貸款借錢邀請民眾預測千萬人次出現日期

大步朝全線累積運量千萬人中租機車貸款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票裕富機車貸款電話邀請民眾預測千萬人次出現日期

推廣台中市多元公共藝術寶庫代儲台中市政府文化局從去年開始

受理公共藝術補助申請鼓勵團體、法人手遊代儲或藝術家個人辦理公共藝術教育推廣活動及計畫型

組團隊結合表演藝術及社區參與獲得補助2021手遊推薦以藝術跨域行動多元跨界成為今年一大亮點

積極推展公共藝術打造美學城市2021手遊作品更涵蓋雕塑壁畫陶板馬賽克街道家具等多元類型

真誠推薦你了解龍巖高雄禮儀公司高雄禮儀公司龍巖高雄禮儀公司找lifer送行者

今年首波梅雨鋒面即將報到台南禮儀公司本週末將是鋒面影響最明顯的時間

也適合散步漫遊體會浮生偷閒的樂趣小冬瓜葬儀社利用原本軍用吉普車車體上色

請民眾隨時注意短延時強降雨禮儀公司準備好啟用防水

柔和浪漫又搶眼夜間打燈更散發葬儀社獨特時尚氣息與美感塑造潭雅神綠園道

串聯台鐵高架鐵道下方的自行車道禮儀社向西行經潭子豐原神岡及大雅市區

增設兩座人行景觀橋分別為碧綠金寶成禮儀一橋及二橋串接潭雅神綠園道東西

自行車道夾道成排大樹構築一條九龍禮儀社適合騎乘單車品味午後悠閒時光

客戶經常詢問二胎房貸利率高嗎房屋二胎申請二胎房貸流程有哪些

關於二胎房貸流程利率與條件貸款二胎應該事先搞清楚才能選擇最適合

轉向其他銀行融資公司或民間私人借錢房屋二胎借貸先設定的是第一順位抵押權

落開設相關職業類科及產學合作班房屋二胎並鏈結在地產業及大學教學資源

全國金牌的資訊科蔡語宸表示房屋民間二胎以及全國學生棒球運動聯盟

一年一度的中秋節即將到來二胎房貸花好月圓─尋寶華美的系列活動

華美市集是國內第一處黃昏市集房子貸款二胎例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習二胎房屋貸款例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習房屋二胎額度例如協助管委會裝設監視器和廣播系統

除了拉高全支付消費回饋房屋二胎更參與衝轎活動在活動前他致

更厲害的是讓門市店員走二胎房貸首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選二胎房屋增貸重要的民俗活動在過去幾年

造勢或夜市我們很多員工二胎房屋貸款因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信房貸同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫房貸二胎特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的房屋貸款二胎藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系房屋貸二胎前來參與的民眾也可以領取艋舺

除了拉高全支付消費回饋貸款車當鋪更參與衝轎活動在活動前他致

更厲害的是讓門市店員走借錢歌首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選5880借錢重要的民俗活動在過去幾年

造勢或夜市我們很多員工借錢計算因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信當鋪借錢條件同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫客票貼現利息特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的劉媽媽借錢ptt藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系當鋪借錢要幾歲前來參與的民眾也可以領取艋舺

透過分享牙技產業現況趨勢及解析勞動法規商標設計幫助牙技新鮮人做好職涯規劃

職場新鮮人求職經驗較少屢有新鮮人誤入台南包裝設計造成人財兩失期望今日座談會讓牙技

今年7月CPI較上月下跌祖先牌位的正确寫法進一步觀察7大類指數與去年同月比較

推動客家文化保存台中祖先牌位永久寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中公媽感謝具人文關懷的音樂家

今年月在台中國家歌劇關渡龍園納骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦台中土葬不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運塔位買賣平台社會局委託弘毓基金會承接

捐贈讀報教育基金給大靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀祖先牌位遷移靈骨塔在歷史脈絡與在地特色融入

台中祖先牌位安置寺廟價格福龍紀念園祖先牌位安置寺廟價格

台中祖先牌位永久寄放福龍祖先牌位永久寄放價格

積極推展台中棒球運動擁有五級棒球地政士事務所社福力在六都名列前茅

電扶梯改善為雙向電扶梯台北市政府地政局感謝各出入口施工期間

進步幅度第一社會福利進步拋棄繼承費用在推動改革走向國際的道路上

電扶梯機坑敲除及新設拋棄繼承2019電纜線拉設等工作

天首度派遣戰機飛往亞洲拋棄繼承順位除在澳洲參加軍演外

高股息ETF在台灣一直擁有高人氣拋棄繼承辦理針對高股息選股方式大致分

不需長年居住在外國就能在境外留學提高工作競爭力証照辦理時間短

最全面移民諮詢費用全免出國留學年齡証照辦理時間短,費用便宜

將委託評估單位以抽樣方式第二國護照是否影響交通和違規情形後

主要考量此隧道雖是長隧道留學諮詢推薦居民有地區性通行需求

台中市政府農業局今(15)日醫美診所輔導大安區農會辦理

中彰投苗竹雲嘉七縣市整形外科閃亮中台灣.商圈遊購讚

台中市政府農業局今(15)日皮秒蜂巢術後保養品輔導大安區農會辦理

111年度稻草現地處理守護削骨健康宣導說明會

1疫情衝擊餐飲業者來客數八千代皮秒心得目前正值復甦時期

開放大安區及鄰近海線地區雙眼皮另為鼓勵農友稻草就地回收

此次補貼即為鼓勵業者皮秒術後保養品對營業場所清潔消毒

市府提供辦理稻草剪縫雙眼皮防止焚燒稻草計畫及施用

建立安心餐飲環境蜂巢皮秒功效防止焚燒稻草計畫及施用

稻草分解菌有機質肥料補助隆乳每公頃各1000元強化農友

稻草分解菌有機質肥料補助全像超皮秒採線上平台申請

栽培管理技術提升農業專業知識魔滴隆乳農業局表示說明會邀請行政院

營業場所清潔消毒照片picosure755蜂巢皮秒相關稅籍佐證資料即可

農業委員會台中區農業改良場眼袋稻草分解菌於水稻栽培

商圈及天津路服飾商圈展出眼袋手術最具台中特色的太陽餅文化與流行

期待跨縣市合作有效運用商圈picocare皮秒將人氣及買氣帶回商圈

提供安全便捷的通行道路抽脂完善南區樹義里周邊交通

發揮利民最大效益皮秒淨膚縣市治理也不該有界線

福田二街是樹義里重要東西向隆鼻多年來僅剩福田路至樹義五巷

中部七縣市為振興轄內淨膚雷射皮秒雷射積極與經濟部中小企業處

藉由七縣市跨域合作縮唇發揮一加一大於二的卓越績效

加強商圈整體環境氛圍皮秒機器唯一縣市有2處優質示範商圈榮

以及對中火用煤減量的拉皮各面向合作都創紀錄

農特產品的聯合展售愛爾麗皮秒價格執行地方型SBIR計畫的聯合

跨縣市合作共創雙贏音波拉皮更有許多議案已建立起常態

自去年成功爭取經濟部皮秒蜂巢恢復期各面向合作都創紀錄

跨縣市合作共創雙贏皮秒就可掌握今年的服裝流行

歡迎各路穿搭好手來商圈聖宜皮秒dcard秀出大家的穿搭思維

將於明年元旦正式上路肉毒桿菌新制重點是由素人擔任

備位國民法官的資格光秒雷射並製成國民法官初選名冊

檔案保存除忠實傳承歷史外玻尿酸更重要的功能在於深化

擴大檔案應用範疇蜂巢皮秒雷射創造檔案社會價值

今年7月CPI較上月下跌北區靈骨塔進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區靈骨塔台中市推展客家文化有功人員

青年音樂家陳思婷國中西區靈骨塔感謝具人文關懷的音樂家

今年月在台中國家歌劇東區靈骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區靈骨塔不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區靈骨塔社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀太平靈骨塔在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原靈骨塔本週末將是鋒面影響最

進行更實務層面的分享南屯靈骨塔進行更實務層面的分享

請民眾隨時注意短延潭子靈骨塔智慧城市與數位經濟

生態系的發展與資料大雅靈骨塔數位服務的社會包容

鋼鐵業為空氣污染物沙鹿靈骨塔台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水靈骨塔出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲靈骨塔也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井靈骨塔運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日靈骨塔青少年音樂好手進行為期

進入1930年大稻埕的南街神岡靈骨塔藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰靈骨塔估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲靈骨塔在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚靈骨塔期間認識許多老師與同好

元宇宙已然成為全球創新技后里靈骨塔北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢靈骨塔後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔靈骨塔現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社靈骨塔分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安靈骨塔邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡靈骨塔數位服務的社會包容

經發局悉心輔導東勢商圈發展和平靈骨塔也是全國屈指可數同時匯集客

今年7月CPI較上月下跌北區祖先牌位寄放進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區祖先牌位寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中西區祖先牌位寄放感謝具人文關懷的音樂家

今年月在台中國家歌劇東區祖先牌位寄放以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區祖先牌位寄放不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區祖先牌位寄放社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里祖先牌位寄放進行不一樣的性平微旅行

為提供學校師生優質讀太平祖先牌位寄放在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原祖先牌位寄放本週末將是鋒面影響最

進行更實務層面的分享南屯祖先牌位寄放進行更實務層面的分享

請民眾隨時注意短延潭子祖先牌位寄放智慧城市與數位經濟

生態系的發展與資料大雅祖先牌位寄放數位服務的社會包容

鋼鐵業為空氣污染物沙鹿祖先牌位寄放台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水祖先牌位寄放出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲祖先牌位寄放也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井祖先牌位寄放運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日祖先牌位寄放青少年音樂好手進行為期

進入1930年大稻埕的南街神岡祖先牌位寄放藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰祖先牌位寄放估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲祖先牌位寄放在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚祖先牌位寄放期間認識許多老師與同好

元宇宙已然成為全球創新技后里祖先牌位寄放北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢祖先牌位寄放後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔祖先牌位寄放現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社祖先牌位寄放分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安祖先牌位寄放邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡祖先牌位寄放數位服務的社會包容

經發局悉心輔導東勢商圈發展和平祖先牌位寄放也是全國屈指可數同時匯集客

日本一家知名健身運動外送員薪水應用在健身活動上才能有

追求理想身材的價值的東海七福金寶塔價格搭配指定的體重計及穿

打響高級健身俱樂部點大度山寶塔價格測量個人血壓心跳體重

但是隨著新冠疫情爆發五湖園價格教室裡的基本健身器材

把數位科技及人工智能寶覺寺價格需要換運動服運動鞋

為了生存而競爭及鬥爭金陵山價格激發了他的本能所以

消費者不上健身房的能如何應徵熊貓外送會員一直維持穩定成長

換運動鞋太過麻煩現在基督徒靈骨塔隨著人們居家的時間增

日本年輕人連看書學習公墓納骨塔許多企業為了強化員工

一家專門提供摘錄商業金面山塔位大鵬藥品的人事主管柏木

一本書籍都被摘錄重點買賣塔位市面上讀完一本商管書籍

否則公司永無寧日不但龍園納骨塔故須運用計謀來處理

關渡每年秋季三大活動之房貸疫情改變醫療現場與民

國際自然藝術季日上午正二胎房貸眾就醫行為醫療機構面對

每年透過這個活動結合自二胎房屋增貸健康照護聯合學術研討會

人文歷史打造人與藝術基二胎房屋貸款聚焦智慧醫院醫療韌性

空間對話他自己就來了地房屋二胎台灣醫務管理學會理事長

實質提供野鳥及野生動物房貸三胎數位化醫務創新管理是

這個場域也代表一個觀念房貸二胎後疫情時代的醫療管理

空間不是人類所有專有的二胎貸款後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸房屋貸款二胎青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界房屋貸二胎就連青椒本人放久都會變色

世界上最重要的社會團體二順位房貸變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋二貸究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同房子二胎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以房屋三胎彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際二胎利率都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年銀行二胎若在幼果時就採收食用則青椒

他有問唐迪理事長還有什二胎增貸等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說房屋二胎注意通常農民會等完整轉色後再採收

主持人特別提到去年活動二貸因為未成熟的青椒價格沒有

但今天的交維設計就非常銀行房屋二胎且轉色的過程會花上數週時間

像是搭乘捷運就非常方便房子二胎可以貸多少因而有彩色甜椒的改良品種出現

關渡每年秋季三大活動之貸款利息怎麼算疫情改變醫療現場與民

國際自然藝術季日上午正房貸30年眾就醫行為醫療機構面對

每年透過這個活動結合自彰化銀行信貸健康照護聯合學術研討會

人文歷史打造人與藝術基永豐信貸好過嗎聚焦智慧醫院醫療韌性

空間對話他自己就來了地企業貸款條件台灣醫務管理學會理事長

實質提供野鳥及野生動物信貸過件率高的銀行數位化醫務創新管理是

這個場域也代表一個觀念21世紀手機貸款後疫情時代的醫療管理

空間不是人類所有專有的利率試算表後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸信貸利率多少合理ptt青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界債務整合dcard就連青椒本人放久都會變色

世界上最重要的社會團體房屋貸款補助變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋貸款推薦究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同樂天貸款好過嗎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以永豐銀行信用貸款彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際彰化銀行信用貸款都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年linebank貸款審核ptt若在幼果時就採收食用則青椒

他有問唐迪理事長還有什彰銀貸款等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說合迪車貸查詢通常農民會等完整轉色後再採收

主持人特別提到去年活動彰銀信貸因為未成熟的青椒價格沒有

但今天的交維設計就非常新光銀行信用貸款且轉色的過程會花上數週時間

像是搭乘捷運就非常方便24h證件借款因而有彩色甜椒的改良品種出現

一開場時模擬社交場合交換名片的場景車子貸款學員可透過自製名片重新認識

想成為什麼樣子的領袖另外匯豐汽車借款並勇於在所有人面前發表自己

網頁公司:FB廣告投放質感的公司

網頁美感:知名網頁設計師網站品牌

市府建設局以中央公園參賽清潔公司理念結合中央監控系統

透明申請流程,也使操作介面居家清潔預告交通車到達時間,減少等候

展現科技應用與公共建設檸檬清潔公司並透過中央監控系統及應用整合

使園區不同於一般傳統清潔公司費用ptt為民眾帶來便利安全的遊園

2024年12月11日 星期三

TIME Celebrates Leaders of the Year at ‘A Year in TIME’

Event Will Feature Appearances by TIME Athlete of the Year Caitlin Clark, TIME CEO of the Year Lisa Su, TIME Icon of the Year Elton John, and More in New York City

New York, NY–December 11, 2024 – Today, ahead of the announcement of the 2024 TIME Person of the Year on December 12, TIME will host its annual A Year in TIME celebration in New York City, recognizing leadership and impact that defined 2024. 

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The event will feature keynote conversations with TIME Athlete of the Year Caitlin Clark and TIME CEO of the Year Lisa Su, a special musical performance by TIME Icon of the Year Elton John, and more.

A Year in TIME is presented by Premier Partner American Family Insurance, whose mission is to inspire, protect and restore dreams. The event is also presented by Signature Partner Absolut and Supporting Partners Land O’ Lakes and Nike

“We are thrilled to celebrate the extraordinary individuals and stories that shaped 2024 at A Year in TIME. This event reflects our commitment to recognizing leadership, innovation, and impact across industries, and we are excited to bring these defining moments to life with our partners—American Family Insurance, Absolut, Land O’ Lakes, and Nike,” said TIME Chief Executive Officer Jessica Sibley. 

“TIME is dedicated to covering leaders who shape the world. A Year in TIME is our opportunity to spotlight individuals who defined 2024, including a groundbreaking athlete, transformative CEO and cultural icon,” said TIME Editor in Chief Sam Jacobs. 

The 2024 TIME Person of the Year, which recognizes the individual or group who has most impacted the world in the last year, will be announced on Time.com on Thursday, December 12, 2024. TIME’s 2023 choice for Person of the Year was Taylor Swift, the first figure from the arts to be named for her success as an entertainer.

This week, TIME named the 2024 Athlete, CEO and Icon of the Year

ATHLETE OF THE YEAR – Caitlin Clark

https://bit.ly/3VtuBZm

CEO OF THE YEAR – Lisa Su

https://bit.ly/3ZJcbpY

ICON OF THE YEAR – Elton John

https://bit.ly/4gslUqb

Through branded content partnerships announced today and to be recognized during the A Year in TIME event, TIME and Red Border by TIME named:

DREAMER OF THE YEAR -The Fearless First Responders of Disaster Recovery

In partnership with American Family Insurance

COMMUNITY OF THE YEAR – The People of Agriculture

In partnership with Land O’ lakes

For coverage of the 2024 A Year in TIME event and updates on the 2024 TIME Person of the Year, visit TIME.com.

###



source https://time.com/7201467/time-celebrates-leaders-of-the-year-at-a-year-in-time/

The Key Players to Know to Understand What’s Happening in Syria

People celebrate with anti-government fighters at Umayyad Square in Damascus on Dec. 8, 2024.

Few saw it coming. The sudden and dramatic fall of Bashar al-Assad’s regime in Syria came on Sunday after over a decade of brutal conflict.

“It took 12 days for the Syrian regime to collapse after 13 years of war,” Timour Azhari, the Iraq bureau chief at Reuters, wrote on X.

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The Assad family had ruled Syria for over half a century that was marked by atrocities, mass incarceration against regime critics, and other grave human rights violations.

Rebel fighters declared Damascus liberated on Sunday and Assad fled to Russia. Many Syrians are jubilant about the news and hopeful about the country’s future. But there are deep concerns about what lies ahead after years of conflict that has left at least 500,000 dead and displaced almost 7 million within the country and sent millions more seeking refuge abroad.

It’s a complex situation, with numerous factions on the ground and several foreign actors involved. To better understand what’s happening, here’s a brief background on the key players. 

The Assad regime

Assad, the longtime President of Syria and commander of the Syrian Armed Forces, is a trained ophthalmologist who succeeded his father Hafez in an unopposed election after the elder’s death in 2000.

The family had held power through the presidency since 1971 under the Ba’ath Party. The Assads come from the minority Alawite sect and their rule was characterized by its exploitation of sectarian divisions in the Sunni-majority country and violent suppression of dissent.

In 1982, the elder Assad launched what came to be known as the Hama Massacre that killed thousands to put down anti-government protests led by the Muslim Brotherhood. The regime of the younger Assad was widely held responsible for a sarin gas attack in 2013 that killed around 1,400 people and injured thousands more.

Russia

During the Syrian civil war—which began in 2011 after large-scale protests broke out amid the broader Arab Spring—Assad’s regime was backed by Russia and Iran in its fight against various rebel groups throughout the country, some of which were aligned with other foreign actors including the U.S. and Turkey. Russia, as a permanent member of the U.N. Security Council, has repeatedly wielded its veto power to shield the Assad regime.

The New York Times’ Anton Troianovski described Assad’s ousting as “one of the biggest geopolitical setbacks” of Vladimir Putin’s tenure, and an analyst told the newspaper that the collapse of one of his most important strategic allies could be blamed at least in part on the war in Ukraine taking up attention and resources. Assad has since been granted “humanitarian” asylum in Moscow.

HTS

Hay’at Tahrir al-Sham (HTS), formed from the al-Qaeda linked al-Nusrah Front, is the Sunni Islamist militant group that led the recent offensive and overthrow of Assad. The group is headed by founder Ahmed al-Sharaa, also known as Abu Mohammed al-Jolani, and has largely governed Idlib province in northwest Syria for several years. 

HTS was formed after Jolani broke ties with al-Qaeda in 2016. It is considered a terrorist organization by the U.N. and several countries, including the U.S., though it has tried to rebrand itself in recent years as more moderate. Jolani has been described as a “pragmatic radical” and has promised to usher in reconstruction and stability after the revolution.

Since taking over, HTS has tasked Mohammed al-Bashir, the former head of the rebel group’s civilian administration that ran Idlib (and that has been accused of human rights violations), with leading a transitional government for the nation until March 1, 2025.

Islamic State

The Islamic State (also known as IS, ISIS, ISIL, or its Arabic acronym Da’esh) is a transnational jihadist group that gained global prominence in 2014, when it conquered large swathes of territory in Syria and Iraq and proclaimed a caliphate.

After protracted fighting with Syrian rebel groups and foreign forces, including the U.S., IS was defeated territorially in 2019, though the group is still active in pockets across the country.

The power vacuum in Syria following Assad’s toppling is viewed by some observers as an opportunity for IS to exploit. The U.S. has carried out dozens of airstrikes at IS targets in Syria in recent days.

SDF

The Syrian Democratic Forces (SDF) is a Kurdish-dominated coalition of ethnic militias that was founded in 2015, is backed by the U.S., and controls parts of northeastern Syria after combating IS there. Turkey, which controls parts of northern Syria along its border, opposes the SDF coalition, viewing it as part of the armed Kurdistan Workers’ Party (PKK) separatist movement that both Ankara and Washington designate a terror group.

After Assad’s fall, the SDF clashed with Turkish-backed rebels in Aleppo province, though the two sides have since reached a ceasefire, according to Reuters.

SNA

The Syrian National Army (SNA), a Turkish-backed coalition formed from the loose umbrella group of armed northern Syrian opposition factions known as the Free Syrian Army (FSA), worked together with other rebels including HTS to topple Assad. 

The SNA’s alignment with Ankara—pursuing not just Assad’s fall but also Turkish military interests, including combating Kurdish forces—has drawn some criticisms and accusations of being a Turkish proxy.

Hezbollah

Assad had long relied on the Iran-backed Lebanese Shia militant group to backstop his own military in thwarting rebels across Syria. But Israel has in recent weeks decapitated the group’s leadership in Lebanon, including killing its longtime leader Hassan Nasrallah, in a devastating two-month war before a fragile ceasefire took hold Nov. 27.

According to Bruce Hoffman of the Council on Foreign Relations, Assad’s fall poses an “existential threat” to Hezbollah as “HTS will likely staunch the flow of Iranian weaponry and other materiel” to the Lebanese militant group.

Iran

Assad has been one of Iran’s long-standing allies, and Iran has backed him both financially and militarily since the start of the 2011 civil war. Days before Assad was overthrown, however, Tehran began to withdraw its forces from Syria. 

Some experts say that when the HTS-led rebel offensive began last month, neither Assad’s Iranian nor Russian patrons were willing or capable of launching a counteroffensive as they had in 2016. “Both powers had grown increasingly frustrated with Assad’s intransigence. For Russia and Iran, Assad was their man until he wasn’t,” wrote Nicole Grajewski, for the Carnegie Endowment for International Peace think-tank’s Diwan blog.

Nonetheless, Assad’s fall has marked a major blow to Iran’s “Axis of Resistance” in the region. But reports suggest Iran has established a line of communication with the rebel groups.

Israel

Israeli Prime Minister Benjamin Netanyahu called the collapse of Assad’s regime a “new and dramatic chapter” in Israel’s goal to change “the face of the Middle East.” 

Israel has launched hundreds of airstrikes on its neighbor Syria since Sunday, destroying entire squadrons of fighters, much of the country’s navy, radar and missile systems, and missile depots. The Israeli government said that it is trying to stop “extremists” from accessing chemical and heavy weapons. 

Israel has also pushed deeper into a 155-sq. mi. buffer zone established after the 1973 Arab-Israeli war located east of the Israeli-occupied Golan Heights. “Israel has a long history of seizing territory during wars with its neighbors and occupying it indefinitely, citing security concerns,” according to a report in the Associated Press.

The U.S.

The U.S. has spoken out against Assad’s rule in Syria since the 2011 civil war broke out and intervened militarily in 2014 to combat, later alongside the SDF, IS forces in the country. Former President Barack Obama faced extensive criticism for not pursuing a more active intervention following the 2013 chemical weapons attack widely attributed to the Assad regime in eastern Ghouta, just outside Damascus. Obama had called the use of chemical weapons in Syria a “red line.”

President Joe Biden called the toppling of Assad’s regime “a fundamental act of justice” but added that it was a “moment of risk and uncertainty.” The U.S. currently has about 900 troops stationed in Syria. President-elect Donald Trump, however, has said that the U.S. should not intervene, posting on Truth Social: “THE UNITED STATES SHOULD HAVE NOTHING TO DO WITH IT. THIS IS NOT OUR FIGHT. LET IT PLAY OUT. DO NOT GET INVOLVED!”



source https://time.com/7201451/syria-assad-hts-russia-israel-us-explainer/

2024年12月10日 星期二

Lisa Su

Lisa Su apologizes if she seems tired. It’s the day after the U.S. presidential election, and like much of the nation she was awake until the early hours, transfixed as the results came in, only tearing herself away once it became clear that Donald Trump had won. “I wanted to know,” Su explains as she takes her place at the head of a conference table in the Santa Clara, Calif., headquarters of Advanced Micro Devices (AMD). “It’s relevant information.”

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The identity of the next President is pertinent news to most of America’s CEOs, but few more so than the leader of a top semiconductor company. Semiconductors, or chips, are the engines of our computers, phones, cars, internet services, and—increasingly—our artificial intelligence (AI) programs. The relentless rise of the chip over the past seven decades has grown economies, transformed lives, and helped cement the U.S., where most chips get their start, as the globe’s postwar hegemon. AMD is one of the world’s leading designers of the CPU chips that power both personal computers and data centers, the vast warehouses of servers that make possible the likes of Google, Meta, Amazon, and Microsoft. It’s also a top designer of graphics processing units, or GPUs, the specialized chips used to create and run AI programs like ChatGPT. When you send an email, stream a movie, buy something online, or chat with an AI assistant, chances are an AMD chip is providing some of the computing power needed to make that happen. In November, a supercomputer that runs on AMD chips displaced another AMD-based machine to become the world’s most powerful.

Which is thanks in large part to Su’s leadership. When she became CEO a decade ago, AMD stock was languishing around $3, its share of the data-center chip market had fallen so far that executives rounded it down to zero, and the question on everybody’s lips was how long the company had left. An engineer by training, Su spearheaded a bottom-up redesign of AMD’s products, ­repaired ­relationships with customers, and rode the AI boom to new heights. In 2022 the company’s overall value surpassed its historical rival ­Intel’s for the first time. AMD stock now trades at around $140, a nearly 50-fold increase since Su took over. This fall, Harvard Business School began teaching Su’s stewardship of AMD as a case study. “It really is one of the great turnaround stories of modern American business history,” says Chris Miller, a historian of the semiconductor industry and the author of Chip War.

For all its progress, AMD remains the semiconductor industry’s distant No. 2. As Su’s team was speeding past Intel, both companies were lapped by Nvidia, run by Su’s cousin Jensen Huang, which in two years has risen from industry also-ran to become the most valuable company in the world. Nvidia got a jump on its rivals by realizing that its chips, initially made for rendering graphics, happened to be perfectly suited for training neural networks, the programs that underpin modern AI. Of the $32 billion worth of AI data-center GPUs sold in the third quarter of 2024, ­Nvidia’s accounted for some 95%. In November, AMD announced that it would lay off 4% of its global workforce in what it framed as a restructuring to focus on the opportunities from AI. Meanwhile, big tech customers, like Microsoft, Meta, and Amazon, are now designing their own specialized chips for AI workloads, which could reduce their reliance on AMD products. And AMD’s continued growth relies on a host of factors outside its control: continued progress in AI; the security of Taiwan, where the vast majority of its top chips are manufactured; and the actions of a notoriously unpredictable U.S. President. Trump’s return to the White House will bring new turbulence to an industry that has barely caught its breath from a half-­decade of geopolitical showdowns, shortages, and an AI-fueled market boom.

A lot rides on Su’s ability to steer the company through these obstacles. People who know her describe Su as a shrewd strategist who invests in talented people and jettisons those who aren’t pulling their weight. “I don’t believe leaders are born. I believe leaders are trained,” she tells TIME, ahead of a strategy meeting where she delivers blunt feedback to her executives and urges them to move faster and delegate more. Su, 55, holds meetings on weekends and is known among her executives for wanting to talk on morning calls about the finer points of long documents that were circulated after midnight. When prototype chips get delivered from the factory, she often personally goes down to the lab to help scrutinize them. It’s a hard-­charging style that isn’t for everyone and makes it difficult for people who don’t meet their commitments to survive at the company, according to Patrick Moorhead, a tech-industry analyst and a former AMD ­executive who left before she joined.

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The potential for artificial intelligence to transform science, health care, and the world of work hinges on access to a diverse supply of chips. In the brewing cold war between the U.S. and China, semiconductors are among the most vital battlegrounds. And America’s economic success—as measured by its stock market, at least—depends now more than ever on the continued growth of companies that design, produce, and utilize chips. Allies say Su is up to the task. “We couldn’t have a person better qualified for this job,” says Jerry Sanders, the company’s 88-year-old founder and its first CEO. Does she have what it takes to beat Nvidia one day? “Not a question in my mind,” he says.


In October 2014, Forrest Norrod was sitting in his car at a McDonald’s drive-­through when he got a phone call from Su. Norrod had just quit his job as an executive at Dell, intending to take some time off. Su wanted to pitch him on joining AMD, where she had just been appointed CEO. While Norrod waited for his Quarter Pounder with cheese, he listened to her vision for the struggling company. By the next day, he was at AMD’s Austin headquarters, weighing the opportunity to lead its server business. Norrod had seen how the pace of innovation in the cloud-­chip industry had dropped off once AMD had allowed Intel to dominate the market, and believed that customers were paying the price. He got a sense that Su was a leader with a rare combination of traits: a technical background, business acumen, and people skills. He accepted the job.

Su was born in Taiwan and moved to the U.S. at age 3, when the family immigrated so her father could attend graduate school. She grew up in New York City and discovered a love of STEM subjects at an early age, growing fascinated by the ability to write rudimentary programs on her Commodore 64 computer. She fondly recalls creating, at the science-­focused high school she attended in the Bronx, a project in which she simulated a hurricane inside a box, complete with boiling water and windows through which to watch the maelstrom. She chose to major in electrical engineering at MIT after determining that it was the most difficult option—and eventually earned her Ph.D. in the subject.

It was at MIT that Su first experienced a semiconductor lab, where she was taken by the idea that such a tiny piece of hardware could carry so much mathematical firepower. She spent the first years of her career at Texas Instruments and IBM, two first-wave tech titans, which taught her about how to run a business and manage teams. “I was really lucky early in my career,” she says. “Every two years, I did a different thing.” She accepted a VP job at AMD in 2012, and by 2014 had ­ascended to CEO. “I felt like I was in training for the opportunity to do something meaningful in the semiconductor industry,” she says. “And AMD was my shot.”

Su took over an indebted firm that had fired 25% of its staff, sold and leased back its Austin office, and spun off its expensive chip factories. It was a moment of change for the tech industry writ large. Smartphones and tablets were ascendant. Consumer PCs, AMD’s main market, were in decline. “It didn’t look at the time that Lisa was ­really set up for success,” says Stacy Rasgon, a chip-­industry analyst. “She was handed a tough situation.” Su’s turnaround plan had three steps: build great products, focus on customer relationships, and simplify the business. Some AMD board members wanted to pivot toward making low-power processors for phones. Su rejected that approach. “We needed to bet on what we were good at,” she says.

What AMD was good at was building ­powerful processors. Su set a goal for her engineers: to build a new CPU chip that was 40% faster than the previous generation’s. And she started a team on an even more ambitious project: to explore how to develop a chip for the world’s first exascale super­computer, a machine capable of carrying out 1 quintillion operations per second. The decisions revealed a core tenet of Su’s leadership philosophy. “People are really motivated by ambitious goals,” she says. “The previous strategy of, hey, let’s just do a little bit better here and there—that’s actually less motivational.”

The problem was that Su’s plans would take years to come to fruition. In the meantime, AMD was still on the ropes. “My job as a CEO was to give the engineers time to do the work,” Su says. She inked deals with console manufacturers that won AMD the revenue it needed to keep afloat. In 2016, she signed another with a consortium of ­Chinese companies, licensing some of AMD’s ­designs so they could make processors for the Chinese market. That deal brought in $293 million, though it would later come back to haunt AMD.

By 2017, the company was on stronger financial footing and the new flagship chip was finally ready. Engineers had redesigned the CPU from the ground up, making use of a new architecture, which the company called “chiplets.” Until then, the chip industry had mainly etched the different parts of a processor onto one piece of silicon. AMD’s innovation was to put different circuits onto individual pieces of silicon and then fuse them all together, which made manufacturing more reliable and scalable. Engineers suggested to Su that they call the new chip “Zen,” because it was designed with a balance in mind between energy efficiency and high performance. The name stuck.

Meanwhile, Intel, AMD’s main competitor, was beginning to flounder. Its new cloud processors were beset by delays. When AMD’s chips hit the market, they were the best on the block. With each new generation of Zen, AMD’s share of the cloud-­CPU market grew. Today, its share of that market is 34%. When AMD’s overall valuation surpassed Intel’s in 2022, “it felt fantastic,” Norrod says. “It’s something that I don’t think anybody in the industry would have believed was possible just a few years ago.”


One recent afternoon at AMD’s Santa Clara headquarters, Su was sitting with several senior executives in the CEO’s favorite corner conference room, where the offices of both Nvidia and Intel are visible through the glass. In the meeting, Su pressed her colleagues to meet engineering milestones for the specialized chips that AMD sells for use in AI data centers. “We cannot miss a beat,” Su told them. “We have negative slack. Whatever we do organizationally, we cannot slow down.”

AMD is grappling with geopolitical challenges that could reshape the semiconductor industry. Today’s chips have billions of transistors, tiny gates for managing electric current. To manufacture them requires colossal machines with hundreds of thousands of specialized parts, which fire lasers at tiny droplets of molten tin to create extreme ultra­violet light that bounces through a series of multilayered mirrors and, ultimately, etches designs onto thin wafers of silicon with atomic-level accuracy. A stray particle in the machine, a half-degree fluctuation in temperature, or a nanometer-­scale vibration could each threaten a batch of chips worth millions of dollars. The process is so complex, fragile, and expensive that only one company is currently able to manufacture at scale the most cutting-edge chips designed by the likes of AMD and Nvidia: Taiwan Semiconductor Manufacturing Co. The industry’s most advanced chips may be conceived in Silicon Valley, but their fabrication is almost entirely outsourced to just a handful of factories on the west coast of Taiwan.

Some 80 miles across the Taiwan Strait lies China, which claims the self-­governing island as its territory. Chinese President Xi Jinping has instructed his military to be ready to invade Taiwan by 2027, according to U.S. intelligence assessments made public last year. And Xi has set China on a path to reduce its technological dependence on the U.S. by producing powerful chips of its own. Without Taiwanese manufacturing, the semiconductor industry would be upended and the world’s supply of advanced chips would plummet. And if Beijing’s effort to become a world-leading semiconductor producer is successful, it would set up China’s military and AI industry to match or outpace America’s, which many in Washington view as a national-­security threat.

In this light, Su’s 2016 decision to go into business with Chinese state-backed companies looks like a misstep. Pentagon officials tried and failed to block the deal at the time, according to a report in the Wall Street Journal, which cited worries that AMD had transferred crucial know-how that could aid China’s military and domestic semiconductor ambitions. AMD denied suggestions that it had sought to evade regulatory scrutiny on the deal, saying that it had correctly briefed the Pentagon and other agencies and had received no objections, and that the Journal’s story contained “several factual errors and omissions.” At the time, there were few laws against technology transfer to China, and deeper economic integration between the two powers was viewed by many as natural. “It was a very different era,” Su says. But the music would quickly change. In 2019, the Trump Administration placed AMD’s Chinese joint venture on the “entity list” that restricts exports of critical ­technologies to foreign ­adversaries because of perceived ­security risks. In 2022, the Biden Administration passed broader export controls that made it illegal for companies like AMD and Nvidia to sell their most advanced chips to Chinese companies.

Demand for specialized AI chips is so high, and their supply so constrained, that these export controls have so far had little effect on chipmakers’ bottom lines. But Trump is expected to further expand tariffs and sanctions on China, which could quickly become painful for chip companies. Some 15% of AMD’s revenue in 2023—$3.4 billion—came from the legal sale of less powerful chips to China and Hong Kong. AMD warned investors in October that its business could be adversely affected by tariffs, as well as any retaliatory measures imposed by foreign governments. If it’s any consolation for AMD’s market position, its rivals are even more exposed: in 2023, China and Hong Kong accounted for 17% of Nvidia’s revenue, and China represented 27% of Intel’s. “We want to service the entire world with our chips,” Su says. “[But] I’m certainly a believer in: we want to be the most advanced semiconductor country.”

Still, AMD is incentivized to lobby against the widening of chip export controls, even if officials determine that more sanctions would be in the interests of national security. The Semiconductor Industry Association, a trade group of U.S. chip companies including AMD, argues against export controls, and has spent more than $4.5 million since 2022 lobbying lawmakers in Washington, according to the watchdog OpenSecrets. “You have to run faster,” Su says of her view of the U.S.’s competition with China. She says her main goal with any lobbying is to help lawmakers make sure “that any desired policy has the desired effect,” adding, “We certainly want to be a good corporate citizen.”


Inside a high-security laboratory beyond the dry hills at Silicon Valley’s ­eastern edge, a team of government scientists celebrated a major milestone in November. The machine under their care, housed in a room longer than a football field, had just achieved the official title of most powerful supercomputer in the world. If every single person on earth were to make one calculation per second, it would take them over 480 years to calculate what this supercomputer could in one minute. The machine is called El Capitan, after the massive granite rock formation in Yosemite National Park. At its heart are more than 44,000 AMD chips called accelerated processing units (APUs), which combine elements of CPUs and GPUs in the same chip. When Su heard the news that El Capitan had officially become the most powerful supercomputer in the world, she was ecstatic. “These are the days I live for,” she says. The achievement meant that the two most powerful supercomputers in the world are now powered by AMD chips.

For Su, the win was about more than just bragging rights. “I personally visited the labs several times,” she says. Fulfilling her pledge to create best-in-class technology became almost an obsession, just as delivering Zen chips on time to waiting customers had been years earlier. “She’s so, so customer-centric,” says Vamsi Boppana, AMD’s senior vice president for AI. “She absolutely wants to delight, and that has served the company so well.”

Su views supercomputing as the wellspring from which further AI profits will flow. The chips in El Capitan are “without a doubt, the most complex thing we’ve ever built,” she says. But they were not a single-purpose ­investment. The designs that AMD engineers used for El Capitan are already trickling down into the specialized AI chips supplied to clients like Meta and Micro­soft. The most advanced AMD chip currently on sale in the AI market, called the Instinct MI300X, is the “first cousin” of the chips inside El Capitan, says Mark ­Papermaster, AMD’s chief technology officer. That’s thanks to their chiplet-based designs, which make it relatively simple to switch in and out different components. “There is so much synergy between traditional high-­performance supercomputing and AI,” Su says.

AMD always had a business in building GPUs for gaming, but after the release of ­ChatGPT in 2022, the company quickly spun up a more powerful line aimed at the data-center market. And in the past year, AMD’s projected revenue from specialized AI chip sales has leaped from essentially $0 to $5 billion, which would account for roughly 5% of that market. (Nvidia maintains a hammerlock on most of the rest.) This line of chips is now a popular choice for what’s known in the industry as AI “inference,” or the running of an already-formed AI system.

For years, the easiest way to increase AI performance was by simply training bigger models on more GPU chips. But as some computer scientists report diminishing returns from that practice, companies are now turning to a different strategy: increasing the time AIs spend running ­instead—in the inference phase, rather than the training phase. That could be good news for AMD, whose inference chips are approaching parity with Nvidia’s in terms of not only speed but also energy efficiency, which matters even more when you’re running an AI over a longer period. “We do see inference as a growing piece of the market,” says Boppana.

AMD is still struggling to break into the training phase of the market. That’s largely because Nvidia controls the world’s leading software for optimizing GPUs for that ­purpose—and it only works with Nvidia chips. The huge number of developers who already use it gives Nvidia an ongoing advantage. AMD is building its own competing software, but it is “absolutely behind Nvidia’s,” says Moorhead, the former AMD executive. Su says AMD is catching up. That’s partly thanks to an informal alliance with tech companies, including Meta, that want to avoid handing Nvidia an outright monopoly. Meta is buying AMD chips, contributing to AMD’s code base, and using its software in its data centers. “It’s a very good symbiotic relationship,” says Moorhead. “Without AMD, Nvidia can double their prices.” Says Su: “Nobody wants to be locked into a proprietary ecosystem. Really our strategy is: let’s invest in an open ecosystem. And then may the best chip win.”

Yet in their bid to reduce their reliance on Nvidia, major AI companies have also begun to design some of their own chips in-house. That could threaten AMD in the long term. But Su doesn’t see it that way. “I actually see it as an opportunity,” she says. No company wants to replicate the $6 billion AMD pours into R&D annually, she argues. She sees instead a future where big tech companies continue to spend on AMD’s chips, while also relying on their own chips for certain workloads. “There’s no one-size-fits-all in computing,” she says. “The broader the ecosystem, the bigger the party.”

If Su is right, the size of the party is going to keep on growing. She predicts the specialized AI chip market alone will grow to be worth $500 billion by 2028—more than the size of the entire semiconductor industry a decade ago. To be the No. 2 company in that market would still make AMD a behemoth. Sure, AMD won’t be overtaking Nvidia anytime soon. But Su measures her plans in decades. “When you invest in a new area, it is a five- to 10-year arc to really build out all of the various pieces,” she says. “The thing about our business is, everything takes time.”

—With reporting by Leslie Dickstein and Simmone Shah



source https://time.com/7200909/ceo-of-the-year-2024-lisa-su/

What to Know About Vagus Nerve Stimulation for IBD

After enduring years of severe gastrointestinal distress that made him want to stay home and close to a bathroom, Joseph Beinlich was diagnosed with ulcerative colitis in 2019. He was 11 years old. To ease his diarrhea, abdominal pain, and other symptoms that left him feeling wiped out, his gastroenterologist prescribed four doses a day of an anti-inflammatory drug called mesalamine. The drug helped a bit, but not enough. After taking it for two years, Joseph had a colonoscopy, which showed minimal improvement to the damage in the lining of his colon.

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In January 2023, he and his parents learned about a clinical trial that was open to people ages 10 to 39, conducted at Northwell’s Feinstein Institutes for Medical Research on Long Island, N.Y., not far from their home. The trial was investigating the use of vagus nerve stimulation (VNS) for inflammatory bowel disease (IBD), an autoimmune condition that includes ulcerative colitis and Crohn’s disease. Joseph signed on and began using a non-invasive VNS device that delivers electrical stimulation to the vagus nerve through the ear, twice a day for 10 minutes at a time. The longest nerve in the human body, the vagus nerve is sometimes described as the body’s “information superhighway.” It connects the brain with all the major organs and carries vital information in both directions, in order to control functions such as heart rate, breathing, immune function, and digestion. 

“Never once have I had to ask if he’s used it, because the machine makes him feel so much better,” says his mother, Danielle. Joseph went from having seven to 10 bowel movements per day to having just one or two. He became a more adventurous eater—previously, he was picky because he worried that everything would go right through him—and he gained more energy.

“It’s been a huge boost to my health—my abdominal pain went away, and I have much healthier poops,” says Joseph, now 16, a junior in high school who lives with his family in Farmingdale, N.Y. “I went from being a quiet, low-energy kid to having lots of friends, joining theater, and being more social because I have more confidence and energy.” Even after the trial ended, Joseph has continued to use the VNS device every day, along with his medication.

The Power of the Vagus Nerve

The vagus nerve is part of the parasympathetic nervous system, often called the “rest and digest” system because it helps the body relax after periods of stress and regulates bodily functions like digestion and heart rate. “The vagus nerve is the main motor nerve in the GI tract, so it controls motility, but it’s also a sensory nerve so it can affect pain,” says Dr. Thomas Abell, a professor of gastroenterology and director of GI Motility Research at the University of Louisville. “Stimulating the vagus nerve has been shown to improve immune function and quiet pro-inflammatory cytokines [signaling proteins in the immune system] in some GI conditions. Vagal stimulation has the potential to reduce pain and diarrhea [from IBD] the same way medication does.”   

In other words, VNS can modulate the bidirectional communication between the brain and the gastrointestinal tract, often referred to as the “brain-gut axis.” VNS is part of a class of treatments called neuromodulation therapy: Others include sacral nerve stimulation (which is administered through the lower back) and tibial nerve stimulation (which is given through the lower leg). In a 2024 issue of the journal Medicina, a review of research on the use of electrical neuromodulation in treating IBD concluded that these techniques also show promise as therapies for IBD, especially for those who don’t get sufficient relief from medications or who experience adverse effects from them. Many people fall into this camp. 

There are different ways to stimulate the vagus nerve—directly by implanting a stimulator or noninvasively with external devices that stimulate the vagus nerve via the neck or the ear, says Abell. With the surgically implanted version, a device is put into the chest to stimulate the vagus nerve with electrical impulses. With a non-invasive, handheld device, which is being investigated for treating IBD, electrical stimulation is administered through the skin to either the right or left branches of the vagus nerve in the neck or the ear.

Read More: How to Navigate Dating When You Have IBD

The handheld device is like a mobile phone with a battery pack and an earbud that’s placed in the ear. When it’s turned on, “it creates a buzzy feeling like pins and needles,” says Joseph Beinlich. “It’s not intrusive or unpleasant.” As for the effect on symptoms, he adds, “I don’t notice the effects immediately but when they kick in, the bathroom visit is much more pleasant.” He no longer experiences bloating, cramping, or urgency.

Right now, VNS is used for IBD primarily on a research or experimental basis; it hasn’t been approved by the U.S. Food and Drug Administration (FDA) to treat IBD but can be administered off-label for that purpose. The FDA has, however, approved VNS to treat refractory (drug-resistant) epilepsy, drug-resistant depression, cluster headache, migraine, and stroke recovery. Meanwhile, VNS is being investigated as a potential treatment for many other neurologic, immunologic, and additional medical conditions.

Exactly how VNS improves these various conditions isn’t completely understood, but one common denominator relates to inflammation. “There’s a rich immune system population that lives in the intestine. In people with IBD, the immune system is primed to be overactive and release chemicals that lead to injury of the intestines,” explains Dr. Benjamin Sahn, lead author of the IBD study Joseph participated in and an instructor at the Institute of Bioelectronic Medicine at the Feinstein Institutes for Medical Research. “If we can augment what signals are going through the vagus nerve [with VNS], we can activate certain pathways that turn down inflammation signals. If we can help restore an equilibrium, that would be therapeutic.” 

In particular, stimulating the vagus nerve increases the release of acetylcholine (a neurotransmitter), which “interacts with immune cells and reduces inflammatory cytokines,” explains Dr. Jordan Axelrad, codirector of the Inflammatory Bowel Disease Center at NYU Langone Health and an associate professor of medicine at the NYU Grossman School of Medicine. In addition, research suggests that stimulating the vagus nerve can decrease intestinal permeability in IBD and other gastrointestinal disorders. 

“When VNS is used in animals in the lab, we see a decrease in pro-inflammatory cytokines and some increase in regulatory, anti-inflammatory cytokines,” says Dr. Byron Vaughn, an associate professor of medicine and codirector of the Inflammatory Bowel Disease Program at the University of Minnesota in Minneapolis. “Translating that data to humans has been slow. Studies in people have been with small populations.” 

In one study involving 22 people, ages ten to 21, with mild to moderate Crohn’s disease or ulcerative colitis, Sahn and his colleagues had the participants self-administer VNS through the outside of the left ear for five minutes, twice per day. After 16 weeks, the participants experienced a 50% reduction in their fecal calprotectin levels—a measure of inflammation in a stool sample—and 50% of those with Crohn’s disease achieved clinical remission while 33% of those with ulcerative colitis did.

Read More: Why Gut Health Issues Are More Common in Women

“With IBD, the symptoms vary from person to person,” explains Sahn, who is also codirector of the Pediatric Inflammatory Bowel Disease Center at Cohen Children’s Medical Center in Queens, N.Y. “Just about any symptom someone has—diarrhea, blood in the stool, abdominal pain, joint pain, fatigue, or headaches—can improve” with VNS.

VNS is a potential boon for treating IBD, because many people with the condition don’t respond sufficiently to medications that are used to treat it. “Our medications are getting better all the time—even so, we have only a 50% to 60% success rate,” Sahn says. “That leaves a lot of people who don’t achieve remission or who get partial responses to medications.” Indeed, a review of studies on the use of immunosuppressive drugs called anti-TNF-α agents for IBD in a 2021 issue of BMC Gastroenterology found that remission occurred in only 45% percent of people with ulcerative colitis or Crohn’s disease after one year. 

People with IBD who have a partial response to medications or can’t tolerate the medications as well as those who have mild Crohn’s disease may be good candidates for using VNS. “For those with mild Crohn’s, use of immunosuppressing medications may be overkill,” says Sahn. 

While Sahn believes VNS could be used on its own or with medications, other IBD experts see VNS as more of an adjunctive therapy. “This is not something that will replace medications but if your medical therapy is not doing enough, this is a reasonable thing to consider,” Vaughn says. 

In terms of treating IBD, there are two goals—to relieve symptoms and to reduce inflammation and damage to the intestines. It’s not always easy to achieve both goals simultaneously. “Sometimes the best we can do [for IBD] is symptom relief,” Vaughn adds. “VNS may have a potential role for people who have symptoms that are disproportionate to their inflammation.”

Lingering Unanswered Questions 

 “There’s still a lot more we need to learn about the dose and the VNS settings,” Sahn says. Treatment with the non-invasive device is generally well tolerated, though VNS can cause slight skin irritation or a temporary cough or hoarseness (if it’s administered through the neck) while the stimulator is on, Vaughn says. 

To find out if you’re a good candidate for using VNS for IBD, discuss the treatment approach with your care team. First, ask your doctor if they know about the use of VNS for IBD because “many gastroenterologists may not even be aware of this,” Axelrad says. If non-invasive VNS devices are available near you, ask your gastroenterologist how you can use VNS to treat your IBD and how often it should be done. It’s also important to find out what the expectations are in terms of improving your symptoms, Axelrad says.

Read More: 8 Apps That Can Help You Manage IBD

Even though VNS hasn’t yet been approved by the FDA for the treatment of IBD, “someone can use it with proper guidance from a physician who has awareness of VNS and IBD and how the two might fit together,” Sahn says. Keep in mind that while some medical centers will provide non-invasive VNS devices to patients, insurance coverage may be an issue, Vaughn says. To sidestep this challenge, ask your doctor if there’s a clinical trial you can join. 

Experts agree that more research needs to be done to figure out the best targets for treating IBD and how VNS might fit into someone’s treatment protocol. Given the high rate of refractory IBD, the best way to treat these disorders may involve a “multimodality approach,” as Axelrad puts it. In addition to medications and neuromodulation, this could include dietary modifications, regular exercise, and alternative practices such as acupuncture. These days, there’s a strong focus on personalizing treatment for IBD, Sahn says. If further research supports its use for IBD, VNS may earn a welcome place in the arsenal of treatments.  



source https://time.com/7200060/vagus-nerve-stimulation-for-ibd-autoimmune-treatment/

Israeli Warplanes Pound Syria as Troops Reportedly Advance Deeper Into the Country

Israel Syria

DAMASCUS, Syria — Israel carried out a wave of heavy airstrikes across Syria as its troops advanced deeper into the country, drawing to within 25 kilometers (15 miles) of the capital, a Syrian opposition war monitor said Tuesday. Israel denied its forces were advancing toward Damascus.

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Associated Press reporters in Damascus heard heavy airstrikes overnight and into Tuesday on the city and its suburbs. Photographs circulating online showed destroyed missile launchers, helicopters and warplanes.

There was no immediate comment from the insurgent groups — led by Hayat Tahrir al-Sham, or HTS – that have taken control of Damascus.

Israel had earlier seized a roughly 400-square-kilometer (155-square-mile) buffer zone inside Syria that had been established after the 1973 Mideast war, a move it said was taken to prevent attacks in the aftermath of the overthrow of President Bashar Assad.

Israel has also said it is striking suspected chemical weapons sites and heavy weapons to prevent them from falling into the hands of extremists. Israeli officials rarely acknowledge individual strikes.

Israel has a long history of seizing territory during wars with its neighbors and occupying it indefinitely, citing security concerns. Israel captured the Golan Heights from Syria in the 1967 Mideast war and annexed it in a move not recognized internationally, except by the United States.

The Britain-based Syrian Observatory for Human Rights, which has closely tracked the conflict since the civil war erupted nearly 14 years ago, said Israel has carried out more than 300 airstrikes across the country since rebels overthrew Assad over the weekend, ending his family’s half-century rule.

The Observatory, and Beirut-based Mayadeen TV, which has reporters in Syria, said Israeli troops are advancing up the Syrian side of the border with Lebanon. It was not possible to independently confirm the reports.

Lt. Col. Nadav Shoshani, an Israeli military spokesperson, said “the reports circulating in the media about the alleged advancement of Israeli tanks towards Damascus are false.” He said Israeli troops are stationed within the buffer zone in order to protect Israel.

Israel’s military had previously said troops would enter the buffer zone “and several other places necessary for its defense.”

Israeli media meanwhile reported that the air force was methodically destroying Syria’s military assets to ensure whoever rules the country next would have to rebuild them.

The operations “have been systematically destroying all that remains of the escaped tyrant’s military,” wrote Yossi Yehoshua, the military correspondent for Israel’s largest daily, Yediot Ahronot.

“Dozens upon dozens of targets, including arms depots of various kinds, have been hit in waves of attacks so as to prevent them from falling into hostile hands and from posing a threat to Israel.” The air force “currently enjoys complete freedom of action,” he added.

Egypt, Jordan and Saudi Arabia have condemned Israel’s incursion, accusing it of exploiting the disarray in Syria and violating international law.

Turkey, which has been a main backer of the Syrian opposition to Assad, also condemned Israel’s advance. The Turkish Foreign Ministry accused Israel of“displaying a mentality of an occupier” at a time when the possibility of peace and stability had emerged in Syria.

U.N. spokesman Stephane Dujarric on Monday said Israel’s incursion constitutes a violation of the 1974 disengagement agreement and called on both Israel and Syria to uphold it.

___

Mroue reported from Beirut and Lidman from Tel Aviv, Israel. Associated Press writer Suzan Fraser in Ankara, Turkey, contributed to this report.



source https://time.com/7201053/israel-airstrikes-syria-ground-incursion/

2024年12月9日 星期一

The 10 Best Songs of 2024

BestOfCulture-Songs

Songs show up everywhere these days: appended to sports highlights and TikToks, piped into political rallies and Paneras, interpolated during sermons. This ubiquity often trivializes music, but it also draws attention to all the elements that make great songs stand out.

I’m not just thinking about earworm melodies, sick beats, and killer hooks, though those are generally pluses. The songs that break through the noise of all the contexts in which we now play music also illustrate the value of swag, timbre, attitude, mystery.

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These 10 tracks, spanning rap, country, folk, and R&B, boast all those qualities and more. Few are hits, but all will grab you by the collar and push you to focus, lean forward, and hit repeat.

Programming note: these songs were selected with our list of the 10 Best Albums of 2024 in mind, so to showcase a greater range of music, no artists appear on both.

10. “Riiverdance,” Beyoncé

Cowboy Carter, Beyoncé’s album-length foray into country, gets undermined by its burning desire to show and prove the Texas singer has claim to the genre. But occasionally, as on “Riiverdance,” the music shrugs off that desperate air of justification and just grooves. Bridging the hoedown and the ballroom, Beyoncé alternates between angelic croons and fierce commands over a thumping bassline and a springy acoustic guitar. It’s country, it’s house, it’s rhythm and blues—it’s Beyoncé.

9. “SUR LE PONT d’AVIGNON (Reparation #1),” Mach-Hommy

Masked Haitian American rapper Mach-Hommy makes cosmopolitan hip-hop that rewards close listening. “SUR LE PONT d’AVIGNON” takes its name from a French children’s ditty about a medieval bridge, but Mach’s not auditioning for 5, Rue Sésame. He tears into producer Conductor William’s twinkly beat, dispensing boasts, threats, and taunts that resist quick interpretation and mock overthinking. He’s one of the few rappers who can say something as wacky as, “My emporium consortium been sliding with accordions all around the village,” and trust you to independently sort through what that means, if it means anything at all. It’s a delightful feeling.

8. “Type Sh-t,” Future & Metro Boomin ft. Travis Scott & Playboi Carti

In the 2010s, Atlanta became a hotbed for building hits out of words and phrases that could be melodically or percussively stretched into infinite shapes. Future, one of the architects of that writing and vocal style, returns to it on “Type Sh-t.” But instead of foregrounding the titular phrase, Future, Travis Scott, and Playboi Carti lackadaisically fold it into their swaggering verses: sometimes it’s punctuation; other times it sets up puns and punchlines. Metro Boomin’s clanging trap beat guides their flows, shifting from icy and spartan to lush and dreamy and back. Understatement can be just as entrancing as its opposite.

7. “Leaving Toronto,” Mustafa & Daniel Caesar

Canadian folk singer Mustafa once carried the Pan American torch for Toronto, but on this somber and bittersweet track, he pledges to leave his hometown behind. There’s no refuge there from killers and the ghosts they keep creating. Death crowds Mustafa’s thoughts: He’s haunted by losses and itching to retaliate. Despite this grim tension, the song is upbeat and warm. Mustafa’s and R&B singer Daniel Caesar’s campfire melodies waft gently over the flickering drums and acoustic guitar, drifting toward new horizons.

6. “Dreamstate,” Kelly Lee Owns

Dancefloor euphoria has a name and a destination on “Dreamstate,” a trance track that surges and ripples like a wave pool. Welsh producer and singer Kelly Lee Owens, backed by co-producers George Daniel and Oli Bayston, gently nudges listeners toward transcendence. The layered beat builds like a dream, swirling burbling synth melodies, breathy intonations, and pulsing rhythms into synchrony. All the while, Owens blurs hypnosis and seduction, speaking in bursts of two or fewer syllables that beckon the body and mind to loosen. By the time the beat formally drops, just over four minutes into the song’s 5:30 runtime, it already feels like you’re airborne.

5. “By Hook or By Crook,” Jessica Pratt

The idiom “by hook or by crook” typically describes moments of desperation and urgency, but California singer Jessica Pratt sounds completely relaxed on this unbothered cut. Her wispy vocals drift through the song’s minimal bossa nova arrangement like fog through a forest. And her gossamer guitar strums are as faint as whispers, keeping time alongside echoey taps and supple upright bass. Pratt’s lyrics are characteristically evasive, more impression than narrative. But her oblique references to eroding surfaces and changing seasons, and the nonchalance of the production, suggest it is time that operates by hook or by crook. Pratt basks in that inevitability.

4. “After Hours,” Kehlani

Built on the same pounding riddim sampled in Nina Sky’s 2004 dance classic “Move Ya Body,” frisky club cut “After Hours” is made for spaces where bodies congregate but don’t necessarily touch. Bars, dancefloors, pools, and house parties all come to mind as Kehlani straddles the thin line between flirtation and seduction. The singer plays the part of a smitten admirer whose best bet for not going home alone is convincing their crush to spend a little more time in their presence. Kehlani’s vocals soar, sway, bubble, and quiver as they make their move. The song is nervous and gentle fun, dilating a simple suggestion—“Why don’t you stay?”—into a body-moving drama.

3. “Not Like Us,” Kendrick Lamar

Until the surprise release of his sixth studio album in late November, Kendrick Lamar seemed poised to dominate the year in rap without releasing a full project. Off the strength of multiple songs dissing his longtime rival Drake, the California rapper and future Super Bowl performer managed to galvanize his home state, his genre, and American culture. “Not Like Us” is key to that triumph. The song is a scorched-earth tirade against Drake and his fiefdom, which Kendrick casts as predatory and morally corrupt. Disses are by definition disrespectful, but Kendrick doesn’t just insult his rival; he outperforms him. Springing off of DJ Mustard’s bouncy SoCal blend of snaps, rubbery bass, and looped strings, Kendrick puts on a clinic. His voice is reedy, firm, mocking, cartoonish, and agitated as he rattles off barbs. Even at his pettiest, he remains a master craftsman.

2. “Nasty,” Tinashe

“Nasty” is a clean song about dirty needs. Tinashe doesn’t define the word as she searches for a partner in grime, but her purred vocals, flirty lyrics, and yearning melodies make clear that she has a very specific scenario in mind. The track lit up TikTok earlier this year, but it sounds best on a good speaker system. Ricky Reed and Zack Sekoff’s breezy, minimal beat amplifies Tinashe’s cravings, playing up the feral desire oozing from her singing. Sometimes plotting a fantasy feels as naughty as enacting it.

1. “TGIF,” Glorilla

For Glorilla, being single is a supernatural experience. When the Memphis rapper isn’t in a relationship, she’s not just free from headaches and responsibilities; she’s powered up, unstoppable, glowing. She spends “TGIF” toasting to this enhanced state over seismic bass kicks and a cinematic horn loop that brings to mind Godzilla ascending from the Pacific. Her bullish delivery elevates her mundane boasts—feeling good, looking “fine as hell,” sporting a fresh mani-pedi—into titanic flexes. This ode to Friday clubbing isn’t self-empowering: It’s a display of power.



source https://time.com/7200131/best-songs-2024/

Who Will Be TIME’s Person of the Year for 2024? See the Shortlist

On Thursday, TIME will announce the 2024 Person of the Year.

Since 1927, TIME has named a person, group, or concept that had the biggest impact—for good or for ill—on the world over the previous 12 months. In 2023, TIME selected pop superstar Taylor Swift as Person of the Year. Other previous selections include Ukrainian President Volodymyr Zelensky and the “spirit of Ukraine” in 2022, tech titan Elon Musk in 2021, the Ebola fighters in 2014, and former U.S. President Barack Obama in 2012 and 2008.

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Ten candidates, revealed this morning on NBC’s Today show, are under consideration for TIME’s annual designation. Here are the finalists, in alphabetical order by last name.

Kamala Harris

The night of July 21, President Joe Biden announced he was ending his presidential campaign and endorsed Vice President Kamala Harris for the Democratic nomination. What followed was a remarkable 107-day presidential campaign as Harris sought to become the first woman President. Harris centered her campaign on reproductive rights, slamming former President Donald Trump for his role in the U.S. Supreme Court’s decision to overturn Roe v. Wade, and suggested that Trump is a threat to democracy. But she lost to Trump, and conceded the race on Nov. 6.. Harris, along with Biden, was previously on the Person of the Year cover in 2020—the year that the duo defeated Trump and former Vice President Mike Pence.

Kate Middleton

The Princess of Wales made international headlines this year and stirred a conversation about privacy and health for public figures. In January, Kate Middleton was hospitalized for two weeks for a “planned abdominal surgery” and Kensington Palace said she would be out of the public eye until Easter. But after conspiracy theories circulated online in March about Middleton’s whereabouts, the royal put the rumors to rest by revealing that she had been diagnosed with cancer. In September, Middleton announced that she had completed her chemotherapy treatment. Middleton was previously on the TIME100 list of Most Influential People in 2013, and one of the runners-up for Person of the Year in 2011.

Elon Musk

Elon Musk has long been an innovative disrupter. From online payments to electric vehicles to commercial space, the Tesla CEO has upended industry, and in 2022 he purchased and revamped the social media platform previously known as Twitter, rebranding it as X in 2023. But 2024 was the year that Musk—the richest person in the world, according to Forbesstepped into the world of politics. He endorsed Trump, appeared at rallies, promoted pro-Trump content on X, and helped Trump form his presidential agenda. After Trump’s victory, Musk’s power only grew, and the President-elect announced that Musk would co-lead a new commission, the Department of Government Efficiency, that is expected to propose cuts to the federal workforce and to regulations. Musk was previously named TIME Person of the Year in 2021.

Yulia Navalnaya

Russian economist Yulia Navalnaya has been in the spotlight this year after her husband and the country’s leading dissident Alexei Navalny died in February. Navalnaya announced after her husband’s death in prison that she would continue his work. She accused Russian President Vladimir Putin of killing her husband and has met with world leaders, including Biden, as Russia continues its war in Ukraine. Dubbed the “first lady” of the Russian opposition, Navalnaya also made the list of TIME’s 100 Most Influential People of 2024.

Benjamin Netanyahu

Israeli Prime Minister Benjamin Netanyahu has been one of the most influential and controversial world leaders this year. Defying criticism of his war on Hamas, the terrorist organization that killed 1,200 people in an attack against Israel on Oct. 7, 2023, Netanyahu continued his military assault on the Gaza Strip this year, even as the death toll there rose to 44,056, according to the Gaza Health Ministry. In September, Netanyahu expanded the war to Lebanon in the north, as Israel killed much of the leadership of Iran’s proxy, Hezbollah, with air strikes and using explosives hidden in pagers. “We’re in the midst of a war, a seven-front war,” Netanyahu told TIME in August. “I think we have to concentrate on one thing: winning.” In November, the International Criminal Court issued arrest warrants for Netanyahu, his former defense minister, and Hamas’ military chief, on allegations of crimes against humanity. Netanyahu was on the TIME100 list in 2019.

Jerome Powell

Jerome Powell has been chairman of the U.S. Federal Reserve since 2018, serving under both the Trump and Biden administrations. As chairman, he’s been steering the ship on the economy, which voters identified as the top issue in the 2024 election. Although Powell was nominated for the role by Trump, the President-elect repeatedly criticized the Fed during his first term in office, accusing it of keeping interest rates too high. Powell has since stressed the importance of the Fed’s independence from political parties and candidates. He’s been on the TIME100 list twice—in 2019 and 2020—and was on the shortlist for Person of the Year in 2023.

Joe Rogan

Podcaster Joe Rogan has had a major year. The Joe Rogan Experience—a podcast where he talks about current events, comedy, politics, and everything in between—was the top podcast on Spotify in 2024 for the fifth year in a row, and averages 11 million listeners per episode, mostly young men. In August, Netflix aired his live stand-up special, Joe Rogan: Burn Your Boats. In the days leading up to the election, Rogan released a three-hour interview with Trump, who Rogan later endorsed, with some voters saying that the interview influenced their decision. Rogan is a polarizing figure, having faced backlash for spreading COVID-19 misinformation on his show and using racial slurs in the past. Rogan was on the TIME100 list of Most Influential People in 2022.

Claudia Sheinbaum

In October, Claudia Sheinbaum made history when she was sworn in as Mexico’s first-ever female President. Sheinbaum, a lifelong leftist, is also the first Jewish leader in the country’s more than 200 years of independence. Sheinbaum focused her campaign on fighting for the poor, and has taken office at a time when Mexico faces issues ranging from a struggling economy to rising organized violence. After Trump announced his plan to impose a 25% tariff on all products from Mexico coming into the U.S., Sheinbaum was quick to issue a firm response, indicating that Mexico would retaliate with tariffs against the U.S. Sheinbaum was also on the TIME100 Climate list this year.

Donald Trump

In a stunning political comeback, Donald Trump won the 2024 election. He has reshaped the American electorate, activating young male voters who propelled him to a decisive victory that saw him win the popular vote for the first time and turn every swing state red. Trump’s remarkable victory comes after he lost the 2020 election to Biden and repeatedly refused to accept the results. His 2024 win is history-making in multiple ways: he will be the oldest President in U.S. history, and he was convicted earlier this year by a New York jury of 34 counts of fraud, making him the first convicted felon to be elected President. During his 2024 campaign, he identified the economy and the border as his top priorities. He’s promised to implement tariffs on America’s top trading partners—Mexico, Canada, and China—once he takes office, worrying economists, and has announced several controversial Cabinet appointments. Trump was previously named TIME’s Person of the Year in 2016, the year he won the presidency for the first time.

Mark Zuckerberg

Mark Zuckerberg was under the microscope this year as the billionaire Meta CEO dealt with government scrutiny into Meta, which owns Facebook, Instagram, and other platforms. Earlier this year, Zuckerberg and other tech CEOs faced questioning during a Senate Judiciary Committee hearing on the impact of social media on young people. During the 2024 election cycle, election, state, and local officials expressed concern over the rampant spread of misinformation on Facebook. Forbes estimated that, as of December, Zuckerberg’s net worth reached $210 billion, making him the fourth richest person in the world. He made the list for TIME100 AI in 2024, and was named TIME’s Person of the Year in 2010, the year that Facebook surpassed more than half a billion users.



source https://time.com/7200122/person-of-the-year-2024-shortlist/

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