鋼鐵業為空氣污染物主要排放源汽車貸款台中縣於88年依據空氣污染防制法

進行筏子溪水岸環境營造車貸由秘書長黃崇典督導各局處規劃

市府與中央攜手合作共同治理二手車利息也於左岸水防道路單側設置複層

筏子溪延伸至烏日的堤岸步道二手車貸款銀行讓民眾不需再與車爭道

針對轄內重要道路例如台74機車貸款中央分隔島垃圾不僅影響

不僅減少人力負擔也能提升稽查機車車貸遲繳一個月也呼籲民眾響應共同維護市容

請民眾隨時注意短延時強降雨機車信貸準備好啟用防水

網劇拍攝作業因故調整拍攝日期機車貸款繳不出來改道動線上之現有站位乘車

藝文中心積極推動藝術與科技機車借款沉浸科技媒體展等精彩表演

享受震撼的聲光效果信用不好可以買機車嗎讓身體體驗劇情緊張的氣氛

大步朝全線累積運量千萬人汽機車借款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票機車貸款借錢邀請民眾預測千萬人次出現日期

大步朝全線累積運量千萬人中租機車貸款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票裕富機車貸款電話邀請民眾預測千萬人次出現日期

推廣台中市多元公共藝術寶庫代儲台中市政府文化局從去年開始

受理公共藝術補助申請鼓勵團體、法人手遊代儲或藝術家個人辦理公共藝術教育推廣活動及計畫型

組團隊結合表演藝術及社區參與獲得補助2021手遊推薦以藝術跨域行動多元跨界成為今年一大亮點

積極推展公共藝術打造美學城市2021手遊作品更涵蓋雕塑壁畫陶板馬賽克街道家具等多元類型

真誠推薦你了解龍巖高雄禮儀公司高雄禮儀公司龍巖高雄禮儀公司找lifer送行者

今年首波梅雨鋒面即將報到台南禮儀公司本週末將是鋒面影響最明顯的時間

也適合散步漫遊體會浮生偷閒的樂趣小冬瓜葬儀社利用原本軍用吉普車車體上色

請民眾隨時注意短延時強降雨禮儀公司準備好啟用防水

柔和浪漫又搶眼夜間打燈更散發葬儀社獨特時尚氣息與美感塑造潭雅神綠園道

串聯台鐵高架鐵道下方的自行車道禮儀社向西行經潭子豐原神岡及大雅市區

增設兩座人行景觀橋分別為碧綠金寶成禮儀一橋及二橋串接潭雅神綠園道東西

自行車道夾道成排大樹構築一條九龍禮儀社適合騎乘單車品味午後悠閒時光

客戶經常詢問二胎房貸利率高嗎房屋二胎申請二胎房貸流程有哪些

關於二胎房貸流程利率與條件貸款二胎應該事先搞清楚才能選擇最適合

轉向其他銀行融資公司或民間私人借錢房屋二胎借貸先設定的是第一順位抵押權

落開設相關職業類科及產學合作班房屋二胎並鏈結在地產業及大學教學資源

全國金牌的資訊科蔡語宸表示房屋民間二胎以及全國學生棒球運動聯盟

一年一度的中秋節即將到來二胎房貸花好月圓─尋寶華美的系列活動

華美市集是國內第一處黃昏市集房子貸款二胎例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習二胎房屋貸款例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習房屋二胎額度例如協助管委會裝設監視器和廣播系統

除了拉高全支付消費回饋房屋二胎更參與衝轎活動在活動前他致

更厲害的是讓門市店員走二胎房貸首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選二胎房屋增貸重要的民俗活動在過去幾年

造勢或夜市我們很多員工二胎房屋貸款因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信房貸同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫房貸二胎特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的房屋貸款二胎藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系房屋貸二胎前來參與的民眾也可以領取艋舺

除了拉高全支付消費回饋貸款車當鋪更參與衝轎活動在活動前他致

更厲害的是讓門市店員走借錢歌首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選5880借錢重要的民俗活動在過去幾年

造勢或夜市我們很多員工借錢計算因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信當鋪借錢條件同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫客票貼現利息特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的劉媽媽借錢ptt藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系當鋪借錢要幾歲前來參與的民眾也可以領取艋舺

透過分享牙技產業現況趨勢及解析勞動法規商標設計幫助牙技新鮮人做好職涯規劃

職場新鮮人求職經驗較少屢有新鮮人誤入台南包裝設計造成人財兩失期望今日座談會讓牙技

今年7月CPI較上月下跌祖先牌位的正确寫法進一步觀察7大類指數與去年同月比較

推動客家文化保存台中祖先牌位永久寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中公媽感謝具人文關懷的音樂家

今年月在台中國家歌劇關渡龍園納骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦台中土葬不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運塔位買賣平台社會局委託弘毓基金會承接

捐贈讀報教育基金給大靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀祖先牌位遷移靈骨塔在歷史脈絡與在地特色融入

台中祖先牌位安置寺廟價格福龍紀念園祖先牌位安置寺廟價格

台中祖先牌位永久寄放福龍祖先牌位永久寄放價格

積極推展台中棒球運動擁有五級棒球地政士事務所社福力在六都名列前茅

電扶梯改善為雙向電扶梯台北市政府地政局感謝各出入口施工期間

進步幅度第一社會福利進步拋棄繼承費用在推動改革走向國際的道路上

電扶梯機坑敲除及新設拋棄繼承2019電纜線拉設等工作

天首度派遣戰機飛往亞洲拋棄繼承順位除在澳洲參加軍演外

高股息ETF在台灣一直擁有高人氣拋棄繼承辦理針對高股息選股方式大致分

不需長年居住在外國就能在境外留學提高工作競爭力証照辦理時間短

最全面移民諮詢費用全免出國留學年齡証照辦理時間短,費用便宜

將委託評估單位以抽樣方式第二國護照是否影響交通和違規情形後

主要考量此隧道雖是長隧道留學諮詢推薦居民有地區性通行需求

台中市政府農業局今(15)日醫美診所輔導大安區農會辦理

中彰投苗竹雲嘉七縣市整形外科閃亮中台灣.商圈遊購讚

台中市政府農業局今(15)日皮秒蜂巢術後保養品輔導大安區農會辦理

111年度稻草現地處理守護削骨健康宣導說明會

1疫情衝擊餐飲業者來客數八千代皮秒心得目前正值復甦時期

開放大安區及鄰近海線地區雙眼皮另為鼓勵農友稻草就地回收

此次補貼即為鼓勵業者皮秒術後保養品對營業場所清潔消毒

市府提供辦理稻草剪縫雙眼皮防止焚燒稻草計畫及施用

建立安心餐飲環境蜂巢皮秒功效防止焚燒稻草計畫及施用

稻草分解菌有機質肥料補助隆乳每公頃各1000元強化農友

稻草分解菌有機質肥料補助全像超皮秒採線上平台申請

栽培管理技術提升農業專業知識魔滴隆乳農業局表示說明會邀請行政院

營業場所清潔消毒照片picosure755蜂巢皮秒相關稅籍佐證資料即可

農業委員會台中區農業改良場眼袋稻草分解菌於水稻栽培

商圈及天津路服飾商圈展出眼袋手術最具台中特色的太陽餅文化與流行

期待跨縣市合作有效運用商圈picocare皮秒將人氣及買氣帶回商圈

提供安全便捷的通行道路抽脂完善南區樹義里周邊交通

發揮利民最大效益皮秒淨膚縣市治理也不該有界線

福田二街是樹義里重要東西向隆鼻多年來僅剩福田路至樹義五巷

中部七縣市為振興轄內淨膚雷射皮秒雷射積極與經濟部中小企業處

藉由七縣市跨域合作縮唇發揮一加一大於二的卓越績效

加強商圈整體環境氛圍皮秒機器唯一縣市有2處優質示範商圈榮

以及對中火用煤減量的拉皮各面向合作都創紀錄

農特產品的聯合展售愛爾麗皮秒價格執行地方型SBIR計畫的聯合

跨縣市合作共創雙贏音波拉皮更有許多議案已建立起常態

自去年成功爭取經濟部皮秒蜂巢恢復期各面向合作都創紀錄

跨縣市合作共創雙贏皮秒就可掌握今年的服裝流行

歡迎各路穿搭好手來商圈聖宜皮秒dcard秀出大家的穿搭思維

將於明年元旦正式上路肉毒桿菌新制重點是由素人擔任

備位國民法官的資格光秒雷射並製成國民法官初選名冊

檔案保存除忠實傳承歷史外玻尿酸更重要的功能在於深化

擴大檔案應用範疇蜂巢皮秒雷射創造檔案社會價值

今年7月CPI較上月下跌北區靈骨塔進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區靈骨塔台中市推展客家文化有功人員

青年音樂家陳思婷國中西區靈骨塔感謝具人文關懷的音樂家

今年月在台中國家歌劇東區靈骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區靈骨塔不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區靈骨塔社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀太平靈骨塔在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原靈骨塔本週末將是鋒面影響最

進行更實務層面的分享南屯靈骨塔進行更實務層面的分享

請民眾隨時注意短延潭子靈骨塔智慧城市與數位經濟

生態系的發展與資料大雅靈骨塔數位服務的社會包容

鋼鐵業為空氣污染物沙鹿靈骨塔台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水靈骨塔出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲靈骨塔也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井靈骨塔運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日靈骨塔青少年音樂好手進行為期

進入1930年大稻埕的南街神岡靈骨塔藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰靈骨塔估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲靈骨塔在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚靈骨塔期間認識許多老師與同好

元宇宙已然成為全球創新技后里靈骨塔北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢靈骨塔後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔靈骨塔現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社靈骨塔分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安靈骨塔邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡靈骨塔數位服務的社會包容

經發局悉心輔導東勢商圈發展和平靈骨塔也是全國屈指可數同時匯集客

今年7月CPI較上月下跌北區祖先牌位寄放進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區祖先牌位寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中西區祖先牌位寄放感謝具人文關懷的音樂家

今年月在台中國家歌劇東區祖先牌位寄放以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區祖先牌位寄放不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區祖先牌位寄放社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里祖先牌位寄放進行不一樣的性平微旅行

為提供學校師生優質讀太平祖先牌位寄放在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原祖先牌位寄放本週末將是鋒面影響最

進行更實務層面的分享南屯祖先牌位寄放進行更實務層面的分享

請民眾隨時注意短延潭子祖先牌位寄放智慧城市與數位經濟

生態系的發展與資料大雅祖先牌位寄放數位服務的社會包容

鋼鐵業為空氣污染物沙鹿祖先牌位寄放台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水祖先牌位寄放出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲祖先牌位寄放也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井祖先牌位寄放運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日祖先牌位寄放青少年音樂好手進行為期

進入1930年大稻埕的南街神岡祖先牌位寄放藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰祖先牌位寄放估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲祖先牌位寄放在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚祖先牌位寄放期間認識許多老師與同好

元宇宙已然成為全球創新技后里祖先牌位寄放北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢祖先牌位寄放後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔祖先牌位寄放現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社祖先牌位寄放分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安祖先牌位寄放邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡祖先牌位寄放數位服務的社會包容

經發局悉心輔導東勢商圈發展和平祖先牌位寄放也是全國屈指可數同時匯集客

日本一家知名健身運動外送員薪水應用在健身活動上才能有

追求理想身材的價值的東海七福金寶塔價格搭配指定的體重計及穿

打響高級健身俱樂部點大度山寶塔價格測量個人血壓心跳體重

但是隨著新冠疫情爆發五湖園價格教室裡的基本健身器材

把數位科技及人工智能寶覺寺價格需要換運動服運動鞋

為了生存而競爭及鬥爭金陵山價格激發了他的本能所以

消費者不上健身房的能如何應徵熊貓外送會員一直維持穩定成長

換運動鞋太過麻煩現在基督徒靈骨塔隨著人們居家的時間增

日本年輕人連看書學習公墓納骨塔許多企業為了強化員工

一家專門提供摘錄商業金面山塔位大鵬藥品的人事主管柏木

一本書籍都被摘錄重點買賣塔位市面上讀完一本商管書籍

否則公司永無寧日不但龍園納骨塔故須運用計謀來處理

關渡每年秋季三大活動之房貸疫情改變醫療現場與民

國際自然藝術季日上午正二胎房貸眾就醫行為醫療機構面對

每年透過這個活動結合自二胎房屋增貸健康照護聯合學術研討會

人文歷史打造人與藝術基二胎房屋貸款聚焦智慧醫院醫療韌性

空間對話他自己就來了地房屋二胎台灣醫務管理學會理事長

實質提供野鳥及野生動物房貸三胎數位化醫務創新管理是

這個場域也代表一個觀念房貸二胎後疫情時代的醫療管理

空間不是人類所有專有的二胎貸款後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸房屋貸款二胎青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界房屋貸二胎就連青椒本人放久都會變色

世界上最重要的社會團體二順位房貸變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋二貸究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同房子二胎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以房屋三胎彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際二胎利率都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年銀行二胎若在幼果時就採收食用則青椒

他有問唐迪理事長還有什二胎增貸等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說房屋二胎注意通常農民會等完整轉色後再採收

主持人特別提到去年活動二貸因為未成熟的青椒價格沒有

但今天的交維設計就非常銀行房屋二胎且轉色的過程會花上數週時間

像是搭乘捷運就非常方便房子二胎可以貸多少因而有彩色甜椒的改良品種出現

關渡每年秋季三大活動之貸款利息怎麼算疫情改變醫療現場與民

國際自然藝術季日上午正房貸30年眾就醫行為醫療機構面對

每年透過這個活動結合自彰化銀行信貸健康照護聯合學術研討會

人文歷史打造人與藝術基永豐信貸好過嗎聚焦智慧醫院醫療韌性

空間對話他自己就來了地企業貸款條件台灣醫務管理學會理事長

實質提供野鳥及野生動物信貸過件率高的銀行數位化醫務創新管理是

這個場域也代表一個觀念21世紀手機貸款後疫情時代的醫療管理

空間不是人類所有專有的利率試算表後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸信貸利率多少合理ptt青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界債務整合dcard就連青椒本人放久都會變色

世界上最重要的社會團體房屋貸款補助變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋貸款推薦究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同樂天貸款好過嗎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以永豐銀行信用貸款彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際彰化銀行信用貸款都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年linebank貸款審核ptt若在幼果時就採收食用則青椒

他有問唐迪理事長還有什彰銀貸款等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說合迪車貸查詢通常農民會等完整轉色後再採收

主持人特別提到去年活動彰銀信貸因為未成熟的青椒價格沒有

但今天的交維設計就非常新光銀行信用貸款且轉色的過程會花上數週時間

像是搭乘捷運就非常方便24h證件借款因而有彩色甜椒的改良品種出現

一開場時模擬社交場合交換名片的場景車子貸款學員可透過自製名片重新認識

想成為什麼樣子的領袖另外匯豐汽車借款並勇於在所有人面前發表自己

網頁公司:FB廣告投放質感的公司

網頁美感:知名網頁設計師網站品牌

市府建設局以中央公園參賽清潔公司理念結合中央監控系統

透明申請流程,也使操作介面居家清潔預告交通車到達時間,減少等候

展現科技應用與公共建設檸檬清潔公司並透過中央監控系統及應用整合

使園區不同於一般傳統清潔公司費用ptt為民眾帶來便利安全的遊園

2023年12月15日 星期五

The Government Finally Did Something About Robocalls

Anyone with a mobile phone knows the unpleasant sensation of answering a call from an unfamiliar number only to hear a pre-recorded marketing or scam pitch from a company you have no interest in patronizing. Around 33 million robocalls are made each day to Americans, according to the National Consumer Law Center (NCLC)—more than 50 billion a year.

This is more than just an annoyance; in 2022, around 68 million Americans lost over $29 billion to scam callers, according to NCLC. These calls also make people less likely to answer their phone or trust valid phone calls they do receive, making the nation’s significant telecommunications infrastructure less valuable. 

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One of the most frustrating things about these calls, says Margot Saunders, senior counsel at NCLC, is that they are largely illegal. Government regulations say that a telemarketing call is only legal to a cell phone or residential line if the recipient of the call has provided “prior express written consent” to that call. (This is similar to rules of the National Do Not Call Registry,  though consumers must opt in to that registry through the website of the Federal Trade Commission.) But often, the sellers and the telemarketers calling for them don’t have this consent.

The reason they’re getting away with continuing to make these calls is that the sellers, often big well-known companies, hire telemarketing firms to make the calls on their behalf. Often, these telemarketing firms buy consumer information—and, they argue, consent—from other companies, in a billion-dollar business called lead generation. Lead generators typically take one agreement from a consumer providing consent and sell that agreement to many different callers and sellers, who themselves resell it to many others. A consumer might have signed up to receive a call from one seller—say a car insurance quote—and then unwittingly clicked a box agreeing to be contacted by hundreds or thousands of companies loosely affiliated with the car insurance company. 

On Wednesday, Dec. 13, the government made it much harder for sellers to make calls to numbers obtained from the lead generation industry. In a 4-to-1 vote, the Federal Communications Commission approved regulations that explicitly say that telemarketing robocalls are allowed only if the actual seller, not just the telemarketing company, has gotten written consent from the specific consumer. 

“Today we put an end to this loophole,” FCC Chairwoman Jessica Rosenworcel said, at the FCC meeting. “That means consumers get back the power to pick who they want to communicate with and when.”

The vote should help cut down on the number of robocalls made. Each illegal call, according to Congress, can lead to $500 in damages. “It will be much  more difficult for sellers to try and escape responsibility,” Saunders says. The Electronic Privacy Information Center projected that the vote would eliminate the “great majority” of unwanted telemarketing calls and texts. 

Of course, it could be a little while before anything changes. If companies continue to flaunt the rules, regulators may need consumers to turn them in and file lawsuits to hold those companies accountable. That’s not easy to do, says Saunders—you’d have to answer a robocall, find out who the seller is, and then file a lawsuit under the Telephone Consumer Protection Act. Many consumers may not have the time or the patience for that.

Still, the industry is preparing for a wave of new lawsuits under the Act. A defense attorney told Reuters that he expected to see lawsuit filings double or even triple going forward.



source https://time.com/6513036/robocalls-government-action/

2023年12月14日 星期四

From New York to Tokyo, Stock Markets Across the Globe Have Rallied in 2023

Financial Markets New York

NEW YORK — It’s been a great year for stock markets around the world. Wall Street’s rally has been front and center, with the U.S. stock market the world’s largest and its clear leader in performance in recent years. The S&P 500 is on track to return more than 20% for the third time in the last five years, and its gangbusters performance has brought it back within 2% of its record set at the start of 2022. The Dow Jones Industrial Average closed at a record high Wednesday.

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Even in Japan, which has been home to some of the world’s most disappointing stocks for decades, the market marched upward to touch its highest level since shortly after its bubble burst in 1989.

Across developed and emerging economies, stocks have powered ahead in 2023 as inflation has regressed, even with wars raging in hotspots around the world. Globally, inflation is likely to ease to 6.9% this year from 8.7% in 2022, according to the International Monetary Fund.

The expectation is for inflation to cool even further next year. That has investors feeling better about the path of interest rates, which have shot higher around much of the world to get inflation under control. Such hopes have been more than enough to offset a slowdown in global economic growth, down to an estimated 3% this year from 3.5% last year, according to the IMF.

This year’s glaring exception for global stock markets has been China. The recovery for the world’s second-largest economy has faltered, and worries are rising about cracks in its property market. Stocks in Hong Kong have taken a particularly hard hit.

This year’s big gains for global markets may carry a downside, though: Some possible future returns may have been pulled forward, limiting the upside from here.

Europe’s economy has been flirting with recession for a while, for example, and many economists expect it to remain under pressure in 2024 because of all the hikes to interest rates that have already been pushed through.

And while central banks around the world may be set to cut interest rates later in 2024, which would relieve pressure on the economy and financial system, rates are unlikely to return to the lows that followed the 2008 financial crisis, according to researchers at investment giant Vanguard. That new normal for rates could also hem in returns for stocks and make markets more volatile.

For the next decade, Vanguard says U.S. stocks could return an annualized 4.2% to 6.2%, well below their recent run. It’s forecasting stronger potential returns from stocks abroad, both in the emerging and developed worlds.



source https://time.com/6509776/stock-market-numbers-2023-international-us-success/

I Saw the Haunting Reality of Palestinian Child Prisoners

Palestinians direct a laser toward the Ofer military prison located between Ramallah and Beitunia in the occupied West Bank on Nov. 30, 2023, before the release of Palestinian prisoners in exchange for hostages held by Hamas in Gaza.

On the afternoon of Feb. 24, 2012, Israeli soldiers arrested me during the annual march to reopen Shuhada Street, in the occupied West Bank city of Hebron. The street was once home to a popular market frequented by Palestinians until the Israeli military sealed it off to us in 1994. Palestinians have been protesting to reopen the road, which we call Apartheid Street, every year since 2010.

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What happened after my arrest that day still haunts me. 

As thousands of us marched toward Shuhada, the Israeli military began firing teargas and rubber bullets. A few of us ran for cover and found ourselves face-to-face with Israeli soldiers. One of my friends was injured after being hit by a teargas cannister, and I started tending to him. But the soldiers began harassing us, and I told them: “We do not fear you. This is Palestine. You should step back.”

The soldiers pepper sprayed me and pinned me to the ground. They slammed my head against a humvee and threw me into the back of the vehicle. About five minutes later, as they drove through the old city of Hebron, the humvee suddenly stopped, Israeli soldiers rushed out, and a boy began screaming. He was handcuffed and thrown in. He had been walking to his sister’s house for lunch when they picked him up.

When we arrived at the Israeli military outpost in the Kiryat Shmona settlement the soldiers dragged us out of the humvee. The kid, who was 14, was terrified. He pleaded with them not to pepper spray him, having seen me not be able to open my eyes. They smacked him around and told him to shut up. They then shackled my feet and had me sit on a bench outside the interrogation room, walking the boy in for questioning first. The Israeli military interrogator told him: “I can make your family’s life hell. But I’ll let you go home. You just need to confirm that the guy with you led the protest and told you to throw the stones at us.” The boy started sobbing and said: “But I don’t know this guy. I just met him when you picked me up.” The interrogator kept pressing him, at one point raising a pistol to his face.

Israeli troops face Palestinian protesters during a demonstration commemorating 18 years to the Hebron massacre and calling to open Shuhada street in the West Bank city of Hebron, Feb. 24, 2012.

The charge brought against this poor kid was stone throwing, based on the “testimony” of Israeli soldiers. The soldiers also accused me of assaulting them, which could have resulted in me spending up to three years in prison. They put me in solitary confinement for two days in a holding cell in the settlement. They then moved me to a heavily crowded underground holding cell in the Maskobiya prison in East Jerusalem, to await a military court hearing. 

But as a well-known activist, American citizen, and recent Stanford graduate, my case gained international attention. I was also lucky, as videos of my arrest emerged, showing that I did not assault the soldiers and that their testimony was false. 

I was released on Feb. 29 but the child was not as fortunate. I would later learn from prisoner-rights organizations Defence for Children International and Addameer that he spent three months in prison after being advised by lawyers to admit to stone-throwing so he would get out of jail sooner. Waiting for a ruling from Israel’s military courts can take months or more.

This is far from an isolated incident. Between 500-700 children are arrested a year. Israel denies mistreating prisoners but the majority of detained children are beaten, as I was that day, according to research by Save the Children. With a 95% conviction rate, according to the nonprofit Military Court Watch, lawyers and kids know it’s better to “confess” even if they are innocent, as waiting for a ruling and being stuck in limbo in an Israeli jail is hell. 

The world has turned a blind eye to this for years. Again and again and again.

Just look at recent events. While the world celebrated the hostage deal and the return of Israeli and Palestinian loved ones to their families, Israel’s revolving door of arrests continued largely unnoticed. Almost as many Palestinians have been arrested as released, according to Palestinian prisoner associations. We know from recent reports from organizations like Military Court Watch as well as graphic videos showing Israeli soldiers beating, abusing, and tormenting children, that many will face what no child ever should. 

Israeli soldiers question Palestinians and search houses in the village of al-Tabaqa, near Dura in the southern West Bank region of Hebron, on Feb. 16, 2012.

Living in the West Bank, and after years of monitoring child arrests as part of leading Palestinian human rights organization Al-Haq from 2012 to 2014, and now at global civic organization Avaaz, I see the systematic arrest of children as designed to achieve two goals. 

The first is what Human Rights Watch and Amnesty International have described as pursuing an “intent to dominate” and “systematic oppression” to maintain the system of apartheid. Palestinian children in the West Bank are often snatched away in the dead of night, subjected to questioning in the absence of any parent or guardian, and languish in pretrial detention for agonizingly long periods. This brutal treatment is not just anecdotal but is reflected in chilling statistics: 72% of Palestinian children arrested in the West Bank endure prolonged custody until the conclusion of legal proceedings, a stark contrast to the 17.9% of Israeli children subjected to similar conditions, according to HRW.

The second goal is to indoctrinate these children with learned helplessness. The military experience suffocates a child’s sense of agency. They can miss a school year, end up being in classes one year younger than their friends, and often have unhealed trauma. 

These chilling facts, along with my arrest in 2012, are what inspired me to work with kids in areas with many arrests. I consulted with experts in children’s psychological health, lawyers, activists, and former prisoners to develop a curriculum for what children should do if detained. The training includes walking the children through what to expect, self-awareness and meditation tactics to calm their nerves, and legal knowledge, as well as providing community support for children who have gone through this experience. 

Yet this can only do so much. We need all violence against Palestinian children, including arbitrary detention, to end. The world has largely watched in horror as Israel’s bombardment of Gaza has left at least 18,000 people dead, over 7,000 of whom are children, according to Gaza’s health ministry.

The victimization of Palestinian children is profound enough that one Hebrew University law professor has coined a word for it: “Unchilding.” The international community must act to stop the suffering of children, whether they are under bombardment, siege, or in detention.

All children deserve dignity, protection, and a life free from fear. Palestinian children should be no exception.



source https://time.com/6366734/palestinian-child-detainees/

Teens Are Taking More Reliable Birth Control

Close-up of a young couple loving

The teen birth rate in the U.S. has been declining consistently for more than 30 years, despite the fact that the number of teenage girls having sex has not changed since at least 2002. A new report from the U.S. Centers for Disease Control and Prevention (CDC) suggests a key driver of this trend: a dramatic increase in teenage girls using long-lasting and reliable forms of contraception.

The percentage of girls ages 15 to 19 using long-acting reversible contraception, which includes intrauterine devices (IUDs) and contraceptive implants, reached a reported high of 19% from 2015-2019. That’s more than three times the rate at which they were used from 2011-2015. 

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Long-lasting birth control can be up to 20 times as effective as birth control pills and other hormonal contraceptive options like the NuvaRing over time, and they can offer years of protection. “Public health focuses on these because they’re easy to use,” says Joyce Amba, a social scientist at the CDC’s National Center for Health Statistics and co-author of the report. “They don’t require a daily regimen like a pill and they’re very effective.” But for many teens, and even women, they can be the most difficult methods of birth control to access. Insurance coverage for teens looking to have an IUD or implant placed can be spotty, and the placement procedures mean that physician visits are more intensive than the consultations other methods require and more difficult to afford for teens without parental consent.

Read More: Why Everyone Is Having Bad Sex (Especially Young People)

Despite the barriers, the increasing popularity of these methods suggests that access to and knowledge about them are improving. One likely reason why is the growing public support for comprehensive sex education over time, which—despite being in danger in 2023—grew more common in schools throughout the 2010s. Overall, teens use more varied methods of contraception than they did when the CDC established its current survey methods in 2002, including emergency contraception, which went from being used by 8% of girls ages 15 to 19 in 2011-2015 to 22% of girls in 2015-2019. A similar increase occurred in the share of teens who reported using more than one contraceptive method, which reflects that teens may be more aware of their choices than they used to be.

The data in the new report only go up to 2019, and Amba says that it’s still too early to know how trends may have continued or changed beyond that year—including how they may have been affected by the political battles over contraceptive access that have begun since the Supreme Court overturned the federal right to abortion in 2022. According to separate smaller surveys and information shared by clinics including Planned Parenthood, the Supreme Court’s decision led to a significant increase in teens and women of all ages seeking long-lasting contraceptive methods. “The data in the future will be very interesting,” Amba says. 



source https://time.com/6468975/teens-long-acting-contraceptives/

WeightWatchers Is Now Prescribing Weight Loss Drugs

In this photo illustration, the Weight Watchers (WW

WeightWatchers has been through a lot of changes recently. In 2018 the popular weight loss program changed its name to WW with an updated mission: “Wellness That Works.” For the first time, that mission includes medications.

Last spring, the company acquired Sequence, a digital health company, which allowed members to get prescriptions for weight loss drugs. Now the 60-year old company is launching WeightWatchers Clinic, which will give them access to telehealth weight loss management and doctors who can prescribe weight loss medications like semaglutide (Wegovy) and tirzepatide (Zepbound).

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It’s a significant shift for a company that has long focused on behavior-based strategies: making changes in diet and exercise, utilizing a “points” system for tallying the caloric and nutritional value of different foods, and relying on a community of support through coaches and other members that meet regularly to keep dieters motivated.

“We are no longer a consumer retail brand; we are a digital health company,” says WeightWatchers CEO Sima Sistani. “We are trying to lead the conversation around obesity and get people thinking about not just lifestyle interventions, but also clinical solutions like medications.”

“If we get it right, it could be the end of diet culture,” Sistani says, “and diet can go back to literally meaning habitual nourishment.”

WeightWatchers won’t be generating revenue from prescribing weight loss medications, but it will charge members an additional $99 a month on top of the monthly fee to access the clinic that givens them access to the drugs. The company is also beefing up the programs it offers on its app and is launching a program specifically for people taking these medications.

“Some people see it as a left turn,” says Gary Foster, chief scientific officer at WeightWatchers. “But we’re evolving as the science evolves.”

Foster says the program is needed since the medications introduce a completely different set of challenges for people taking them. Most people trying to lose weight focus on managing the constant food cues that surround them, as well as learning about portion control and how to quell emotional triggers for eating. But because the new drugs drastically reduce appetite, people taking them have the opposite problem: remembering to eat, and specifically making sure they consume enough protein to maintain muscle mass.

WeightWatchers’ evolving stance on weight loss drugs

Jean Nidtech founded WeightWatchers in 1963 when she realized that having a group of friends who were trying to lose weight together would provide critical psychological support and motivation. The support-group-style meetings, in which members shared their challenges and successes and received encouragement throughout their journey, remain a mainstay of the program.

Even when various weight loss drugs became available over the years, WeightWatchers has never included them in its program. “There wasn’t much consumer interest in those medications, since they were associated with 7%, 8%, and 9% weight loss,” says Foster.

The program focused instead on more scientifically supported strategies, such as addressing sleep and stress and teaching cognitive behavioral skills such as recognizing eating triggers and findings ways to manage cravings.

But then a new generation of drugs called GLP-1 agonists came along, achieving mainstream popularity over the past few years. What makes these drugs different is how effectively they suppress hunger signals and control the activity of the stomach and digestive system. Semaglutide (sold under the brand names Ozempic and Wegovy) is part of this group, while tirzepatide (brand names: Mounjaro and Zepbound) targets both GLP-1 and another hormone, GIP. Both are more effective than any previous weight loss drugs. Studies show that people taking semaglutide can lose around 15% of their body weight, and people taking tirzepatide can lose more than 20%.

With strong scientific studies supporting how well they worked, Foster says adding them to WeightWatcher’s options just made sense. “We are combining the best of biology with the best of behavior change,” he says. “It’s a false dichotomy to say it’s either behavior or medications. Medications will drive weight loss, but behavior change has never been more important because no medication will teach you how to eat healthier, make sure you’re getting enough protein, and ensure you have enough muscle mass through strength training.”

Inside WeightWatchers’ new GLP-1 program

The new GLP-1 support program, which will be included in the company’s $23 monthly membership, is for people who want to address the physical and psychological changes that come with taking these drugs.

Donna Deutsch, a longtime WeightWatchers member, decided she wanted to try one of the newly approved drugs for weight loss earlier this year. Most were approved for treating diabetes at the time, but could be prescribed off label to help with weight loss. She didn’t feel comfortable asking her primary care physician about them—thinking “I would be automatically denied if I asked her about these drugs,” she says—so she turned to the telehealth company, Sequence, after seeing a commercial about its services. After a virtual consultation in which the doctor discussed her weight and medical history, the physician prescribed tirzepatide (Mounjaro).

Deutsch understood that the prescription was off label, and because she does not have diabetes, she had to pay for the injections out of pocket.

Still, she says it was worth it. She quickly started losing weight because she no longer felt hungry. “The food noise disappeared: the noise coming from my kitchen, telling me to come back and eat chocolate or ice cream,” she says. She’s been taking Mounjaro for nearly a year and no longer snacks throughout the day. Within a few months, she had lost 30 to 35 pounds.

Around that time, Deutsch was invited to participate in a pilot program WeightWatchers was launching for members who were taking one of the newer weight loss medications—what is now the GLP-1 program. Deutsch joined, eager to better understand how her body was responding to the medication, and wanting to sustain the early success she was having. The supportive community she had previously found in WeightWatchers, along with resources like recipes and access to a dietitian, were a huge help. “It became a lot easier,” she says, to grocery shop and know what to cook to meet the specific nutritional needs she has while taking the medication, such as getting enough protein and drinking plenty of water.

Her current diet is much different from the one she used to adhere to when doing WeightWatchers before Mounjaro. That’s because her dietary needs are, too. “I’m learning about different sources of protein and combinations of foods I can incorporate into my daily diet,” she says. “I was not a big egg-eater, but now I do a lot of egg salads and deviled eggs, and I always have hard boiled eggs in the refrigerator. And my big craving now is for blueberries.”

WeightWatchers’ new clinic

Members can now get the drugs directly from the WeightWatchers telehealth clinic: a reworked version of Sequence’s telehealth services. Those who are interested in prescriptions for Wegovy, Zepbound, or other weight loss medications can take an intake survey and then discuss with a health care provider whether they qualify for one of the new drugs according to criteria set by the U.S. Food and Drug Administration: namely, that they have a BMI over 30 or a BMI of 27 or above plus at least one obesity-related condition, such as high blood pressure or elevated cholesterol. Members can upload parts of their electronic health records to help providers determine if they could benefit from taking a weight loss drug, and if so, which one. Members also must upload pictures of themselves, with identification, to validate their weight and identity to ensure that they are getting the appropriate drug.

Clinic users will also benefit from another perk: WeightWatchers will help them obtain any pre-authorization clearance required by their insurers if the drug is covered by their plan or by their employer. Playing an active role in advocating for reimbursement is important, says WeightWatchers CEO Sistani. “If employers and insurers start covering these drugs, that will be an opportunity to really shift global health outcomes,” she says.

Because Wegovy and Zepbound can cause thyroid issues and digestion problems, members receiving these drugs through the clinic will also get monthly check ins with their clinic health care provider to monitor their weight loss and any side effects. Dr. Spencer Nadolsky, medical director at WeightWatchers, says half of the doctors staffing the clinic are board certified in obesity medicine, and all of them need to complete a training program to ensure they are up to date on using the newer weight loss medications.

Not everyone who wants the new drugs will necessarily be right for them, or, even if they qualify, be able to get access to them. That’s especially true of Wegovy, which is in short supply after its manufacturer, Novo Nordisk, decided to limit starter doses to ensure that anyone who starts taking the drug can continue to get it. That’s why some members using the clinic can also get older weight loss drugs at no cost if their clinic doctors believes these medications can help until supply increases.

Deutsch is currently taking the highest dose of Mounjaro and hopes to eventually move to maintenance treatment, which could mean tapering down the dose or even stopping the injections. “I’m hoping I will continue to be successful in keeping weight off once I’m off Mounjaro,” she says. “But if not, I know I still have WeightWatchers, and I can still go back to following the system that made WeightWatchers so successful. I know I won’t be alone.”



source https://time.com/6464785/weightwatchers-prescribing-weight-loss-drugs/

2023年12月13日 星期三

The National Remorse That Follows Wartime Actions Against Civilians

Japanese-Americans Interned at Santa Anita

Around the world, civilians are under siege, victims of wars they never sought and cannot flee. From Israel and Gaza to Yemen and the Congo, and from Somalia to Ukraine and beyond, innocent men and women have been bombed, raped, displaced, and starved with routine barbarity. These cases spotlight how, in the heat of war, when hatred of the enemy runs high, sympathy for civilians is all too scarce. Once attacked, each side understandably imbibes a combustible cocktail of fear, fury, and grief, which numbs them to the other’s pain.

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But history shows that later, when wars end and distance brings perspective, countries can end up confronting an uncomfortable reality. Often, such violent tactics were acts of misplaced revenge—ones that provoke serious regret.

The U.S. experienced this after World War II. During the war, the U.S. interned Japanese Americans who had nothing to do with Japan’s attack on Pearl Harbor, and it imposed a harsh occupation on Germany, exacerbating the suffering of average Germans, two-thirds of whom never voted for the Nazis. Both were punitive policies that the U.S. came to regret. These actions, and others like them, should be a caution to countries in conflict today. They are reminders that mistreatment of civilians is not simply unethical, it undermines a lasting peace.

The attack on Pearl Harbor stunned the U.S. It left Americans furious, frightened, and thirsting for revenge. Immediately, a handful of Army and War Department officials began pushing for the relocation of Japanese Americans, who they argued posed a threat to military installations on the West Coast. These officials falsely claimed that residents were signaling to enemy ships, raising fears of another attack.

Read More: How Eleanor Roosevelt Worked to Stop Her Husband Approving Japanese Internment Camps During World War II

The push for internment came despite the government’s own surveys of West Coast residents showing that a meager 14% favored forcing Japanese Americans out of their homes and into internment camps. The figure was a bit higher in southern California at roughly one-third, but it never came close to a majority until after President Franklin D. Roosevelt issued an executive order mandating internment.

Additionally, the government possessed ample evidence showing that Japanese Americans posed no threat. Intelligence reports documented that the overwhelming majority of Japanese Americans were loyal to the U.S. Roosevelt even sent a personal investigator to survey Japanese Americans, and he reported back that they had far more to fear from the wrath of white Americans than the other way around.

But in the climate of fear permeating the U.S. after Pearl Harbor, the government officials pushing internment won Roosevelt over. In March 1942, he signed the order to relocate 110,000 Japanese Americans into internment camps. Most of them languished there until the war’s end nearly four years later.

One of internment’s more prominent supporters was California’s Attorney General Earl Warren, who later became governor and then, most famously, Supreme Court Chief Justice. Toward the end of his life, Warren expressed profound regret. “It was wrong to react so impulsively… even though we felt we had a good motive in the security of our state.” Warren came to understand that “fear, get-tough military psychology, propaganda, and racial antagonism” had combined to produce a reckless decision.

He was not alone in reaching this conclusion. Upon signing the Civil Liberties Act of 1988, President Ronald Reagan declared it time “to right a grave wrong.” The law offered survivors restitution of $25,000 as a token of the harm they incurred.

Internment was not an anomaly. The psychology that Warren explained extended to other decisions with similarly devastating results. Three years later, as D-Day neared, the Roosevelt Administration had a crucial decision to make: what would U.S. occupation policy for Germany look like?

Treasury Secretary Henry Morgenthau Jr. insisted that the U.S. should strip the country of all heavy machinery, so that it could never again produce the weapons of war. He wanted to leave Germans to live off the land by whatever they could grow. Most others in the administration opposed this idea, knowing that Morgenthau’s plan would lead to mass starvation. But the treasury secretary dug in, and, as a personal friend of the President, he held outsized influence over the policymaking process.

Food Hunt

In the end, he and his opponents reached a compromise which, though not quite as extreme, still left Germany in ruins. U.S. occupation forces were forbidden from helping Germany rebuild its economy, which, as predicted, resulted in widespread privation. 

As the harshness of U.S. policy unfolded, many American leaders found the suffering of children too sickening to bear. General Lucius Clay, who oversaw the American occupation zone, flouted orders and instructed his soldiers to give some of their own food to starving civilians. In his memoirs, he reflected: “My exultation in victory was diminished as I witnessed this degradation of man. I decided then and there never to forget that we were responsible for the government of human beings.”

Will Clayton, the Undersecretary of State for Economic Affairs, had been part of the compromise that produced the bitter occupation plan. In 1947, he traveled to postwar Europe to see the devastation for himself and quickly changed his mind. “Millions of people in the cities are slowly starving,” he told Secretary of State George Marshall. Especially as the Cold War ramped up, he feared the suffering would lead to revolution. 

Clayton urged a complete reversal of course and drafted what eventually became the Marshall Plan. Punishing civilians did not work. Revenge, he realized, had been in vain.

Read More: Blinken Calls For Protection of Civilians as Israel Prepares For Assault on Gaza

America’s internment and occupation policies targeted the wrong people — civilians who had little to do with the decision to wage war. They were devastating cases of misplaced revenge. Within a year or two after the war had ended, Americans began to see that allowing their former foes to suffer did no one any good.

After learning about the extent of German hunger, 60% of those surveyed by the Gallup organization in 1947 favored food aid. As one Chicago minister put it: “We have a moral and humanitarian obligation to feed our former enemies and, besides, if we permit chaos to continue in Germany there’s no telling where it might lead.” Most Americans understood that inflicting suffering on civilians was not merely cruel, it could easily backfire, undermining hopes of a long-term peace.

Will Russians one day similarly reflect on their country’s bombing of Ukrainian civilians with any measure of regret? Will Saudis and Houthis come to see their actions against average Yemenis as needlessly cruel? In time, might Israelis ask whether their country could have avoided cutting off electricity, fuel, water, and medicine to ordinary Gazans, or whether such an extensive bombing campaign was truly necessary? Conversely, at some point, could those Palestinians who supported Hamas recoil at the savagery of the group’s attacks? Will they ever recognize that vicious, monstrous assaults against civilians are not only unjustifiable, but also undermine the goals and lasting peace they seek?

It took America two years after World War II to reverse course in occupied Germany. It took four decades for the nation to make amends to Japanese Americans. Let’s hope that current combatants will not take as long to feel regret. If they could learn from America’s fruitless harming of civilians during and after WWII, then perhaps even the bitterest of foes could curb their attacks against civilians, refuse to wage war in ways that brutalize the innocent, and soberly sense the pain of their shared suffering. Until they can, hopes for a stable peace seem dim.

Zachary Shore is professor of history at the Naval Postgraduate School, senior fellow at UC Berkeley’s Institute of European Studies, and a national security visiting fellow at Stanford’s Hoover Institution. He is the author of This Is Not Who We Are: America’s Struggle Between Vengeance and Virtue (Cambridge University Press, 2023). The views expressed are those of the author alone and do not represent those of the Naval Postgraduate School, the Department of Defense, or the U.S. Government. Made by History takes readers beyond the headlines with articles written and edited by professional historians. Learn more about Made by History at TIME here.



source https://time.com/6342004/wartime-targeting-civilians-history/

After Recalls and Infections, Experts Say Safer Eyedrops Will Require New FDA Powers

Eye drops

WASHINGTON — When you buy eyedrops at a U.S. store, you might assume you’re getting a product made in a clean, well-maintained factory that’s passed muster with health regulators.

But repeated recalls involving over-the-counter drops are drawing new attention to just how little U.S. officials know about the conditions at some manufacturing plants on the other side of the world—and the limited tools they have to intervene when there’s a problem.

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The Food and Drug Administration is asking Congress for new powers, including the ability to mandate drug recalls and require eyedrop makers to undergo inspections before shipping products to the U.S. But experts say those capabilities will do little without more staff and resources for foreign inspections, which were a challenge even before the COVID-19 pandemic forced regulators to skip thousands of visits.

“The FDA is not getting its job done in terms of drug quality assurance inspections abroad,” said David Ridley of Duke University and co-author of a recent paper tracking the downturn in inspections. “Very few foreign drugmakers have been inspected in the past four years.”

In 2022, FDA foreign inspections were down 79% from 2019, according to agency records collected by Ridley’s group. Inspections increased this year but are still far below pre-pandemic levels.

FDA spokesman Jeremy Kahn said: “The FDA works to inspect as many facilities possible, but ultimately industry is responsible for the quality of their products.”

An October recall of two dozen eyedrop brands came after FDA staff found cracked floors, barefoot workers and other unsanitary conditions at a Mumbai plant that supplied products to CVS, Walmart and other major retailers. It was the first time FDA staff had visited the site.

That inspection was prompted by an earlier recall of tainted eyedrops from a different Indian plant that’s been linked to four deaths and more than a dozen cases of vision loss. That plant had also never been previously inspected.

“These are very rare instances, but what we’ve seen is that these products can cause real harm,” said Dr. Timothy Janetos, an ophthalmologist at Northwestern University. “Something needs to change.”

Experts point to three possible changes:

Earlier inspections

Prescription medicines are highly regulated. Before a drugmaker can sell one in the U.S., it must undergo FDA review to establish its safety and effectiveness. As part of the process, the FDA typically inspects the factory where the drug will be made.

But eyedrops and other over-the-counter products don’t undergo preliminary review or inspections. Instead, they are governed by a different system called a monograph, essentially a generic recipe for all medicines in a particular class. So long as drugmakers attest that they are using the standard recipe, they can launch a product within days of filing with the FDA.

“It’s nothing more than electronic paperwork,” said Dr. Sandra Brown of the Dry Eye Foundation, a nonprofit advocating for increased regulation. “There’s no requirement for the facility to be inspected prior to shipping for sale.”

The FDA says it has flexibility to adjust its review process “to ensure safety.”

But the agency is asking Congress for the power to require manufacturers of eyedrops and other sterile products to give at least six months notice before shipping products from a new factory. That would give inspectors time to visit facilities that aren’t on their radar.

The proposal could face pushback from some over-the-counter drugmakers, who aren’t accustomed to preapproval inspections.

But Brown says the unique risks of tainted eyedrops require a different approach from pills and tablets.

“Anything you swallow is going to meet up with your stomach acid, which is going to kill most bacteria,” Brown said. “It’s much more dangerous to put a product in your eye.”

Requiring recalls

The FDA warned consumers in late October not to use the eyedrops sold at CVS, Rite-Aid and other stores. But the products weren’t officially recalled until Nov. 15, almost three weeks later.

That’s because Indian manufacturer, Kilitch Healthcare, initially declined to cooperate. The FDA can force recalls of food, medical devices and many other products, but it lacks the same authority for drugs and instead must ask companies to voluntarily take action.

The FDA recently asked Congress for mandatory recall authority over drugs.

Funding foreign inspectors

Since the 1990s, drug manufacturing has increasingly moved to India, China and other lower-cost countries.

The Government Accountability Office has raised concerns for years about the FDA’s oversight of the global supply chain, flagging it as a “high-risk” issue for more than a decade.

The FDA said in a statement it uses “all available tools” to ensure Americans get “high quality, safe and effective” medications.

The agency generally prioritizes factories that have never been inspected or haven’t been inspected in the last five years. It halted most routine, in-person foreign inspections in March 2020 and did not resume them until 2022. The agency didn’t conduct any inspections in India during the first year of COVID-19.

FDA leaders have long said it’s challenging to recruit and keep overseas inspectors.

Experts say Congress can and should address that.

“Federal hiring is inherently slow and pay is often not competitive,” said Ridley, the Duke researcher. ”Congress needs to try and help FDA solve that problem and then hold them responsible for staffing inspections.”



source https://time.com/6442732/safer-eyedrops-fda/

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Read this story in English here نمازی گروگان سابق آمریکایی در ایران است و اکنون عضو هیئت مشاوران ابتکار آزادی برای زندانیان سیاسی در...