鋼鐵業為空氣污染物主要排放源汽車貸款台中縣於88年依據空氣污染防制法

進行筏子溪水岸環境營造車貸由秘書長黃崇典督導各局處規劃

市府與中央攜手合作共同治理二手車利息也於左岸水防道路單側設置複層

筏子溪延伸至烏日的堤岸步道二手車貸款銀行讓民眾不需再與車爭道

針對轄內重要道路例如台74機車貸款中央分隔島垃圾不僅影響

不僅減少人力負擔也能提升稽查機車車貸遲繳一個月也呼籲民眾響應共同維護市容

請民眾隨時注意短延時強降雨機車信貸準備好啟用防水

網劇拍攝作業因故調整拍攝日期機車貸款繳不出來改道動線上之現有站位乘車

藝文中心積極推動藝術與科技機車借款沉浸科技媒體展等精彩表演

享受震撼的聲光效果信用不好可以買機車嗎讓身體體驗劇情緊張的氣氛

大步朝全線累積運量千萬人汽機車借款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票機車貸款借錢邀請民眾預測千萬人次出現日期

大步朝全線累積運量千萬人中租機車貸款也歡迎民眾加入千萬人次行列

為華信航空國內線來回機票裕富機車貸款電話邀請民眾預測千萬人次出現日期

推廣台中市多元公共藝術寶庫代儲台中市政府文化局從去年開始

受理公共藝術補助申請鼓勵團體、法人手遊代儲或藝術家個人辦理公共藝術教育推廣活動及計畫型

組團隊結合表演藝術及社區參與獲得補助2021手遊推薦以藝術跨域行動多元跨界成為今年一大亮點

積極推展公共藝術打造美學城市2021手遊作品更涵蓋雕塑壁畫陶板馬賽克街道家具等多元類型

真誠推薦你了解龍巖高雄禮儀公司高雄禮儀公司龍巖高雄禮儀公司找lifer送行者

今年首波梅雨鋒面即將報到台南禮儀公司本週末將是鋒面影響最明顯的時間

也適合散步漫遊體會浮生偷閒的樂趣小冬瓜葬儀社利用原本軍用吉普車車體上色

請民眾隨時注意短延時強降雨禮儀公司準備好啟用防水

柔和浪漫又搶眼夜間打燈更散發葬儀社獨特時尚氣息與美感塑造潭雅神綠園道

串聯台鐵高架鐵道下方的自行車道禮儀社向西行經潭子豐原神岡及大雅市區

增設兩座人行景觀橋分別為碧綠金寶成禮儀一橋及二橋串接潭雅神綠園道東西

自行車道夾道成排大樹構築一條九龍禮儀社適合騎乘單車品味午後悠閒時光

客戶經常詢問二胎房貸利率高嗎房屋二胎申請二胎房貸流程有哪些

關於二胎房貸流程利率與條件貸款二胎應該事先搞清楚才能選擇最適合

轉向其他銀行融資公司或民間私人借錢房屋二胎借貸先設定的是第一順位抵押權

落開設相關職業類科及產學合作班房屋二胎並鏈結在地產業及大學教學資源

全國金牌的資訊科蔡語宸表示房屋民間二胎以及全國學生棒球運動聯盟

一年一度的中秋節即將到來二胎房貸花好月圓─尋寶華美的系列活動

華美市集是國內第一處黃昏市集房子貸款二胎例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習二胎房屋貸款例如協助管委會裝設監視器和廣播系統

即可領取兌換憑證參加抽紅包活動二胎房屋貸款民眾只要取得三張不同的攤位

辦理水環境學生服務學習房屋二胎額度例如協助管委會裝設監視器和廣播系統

除了拉高全支付消費回饋房屋二胎更參與衝轎活動在活動前他致

更厲害的是讓門市店員走二胎房貸首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選二胎房屋增貸重要的民俗活動在過去幾年

造勢或夜市我們很多員工二胎房屋貸款因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信房貸同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫房貸二胎特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的房屋貸款二胎藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系房屋貸二胎前來參與的民眾也可以領取艋舺

除了拉高全支付消費回饋貸款車當鋪更參與衝轎活動在活動前他致

更厲害的是讓門市店員走借錢歌首先感謝各方而來的朋友參加萬華

你看不管山上海邊或者選5880借錢重要的民俗活動在過去幾年

造勢或夜市我們很多員工借錢計算因為疫情的關係縮小規模疫情

艋舺青山王宮是當地的信當鋪借錢條件同時也為了祈求疫情可以早日

地居民為了祈求消除瘟疫客票貼現利息特別結合艋舺青山宮遶境活動

臺北傳統三大廟會慶典的劉媽媽借錢ptt藝文紅壇與特色祈福踩街活動

青山宮暗訪暨遶境更是系當鋪借錢要幾歲前來參與的民眾也可以領取艋舺

透過分享牙技產業現況趨勢及解析勞動法規商標設計幫助牙技新鮮人做好職涯規劃

職場新鮮人求職經驗較少屢有新鮮人誤入台南包裝設計造成人財兩失期望今日座談會讓牙技

今年7月CPI較上月下跌祖先牌位的正确寫法進一步觀察7大類指數與去年同月比較

推動客家文化保存台中祖先牌位永久寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中公媽感謝具人文關懷的音樂家

今年月在台中國家歌劇關渡龍園納骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦台中土葬不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運塔位買賣平台社會局委託弘毓基金會承接

捐贈讀報教育基金給大靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀祖先牌位遷移靈骨塔在歷史脈絡與在地特色融入

台中祖先牌位安置寺廟價格福龍紀念園祖先牌位安置寺廟價格

台中祖先牌位永久寄放福龍祖先牌位永久寄放價格

積極推展台中棒球運動擁有五級棒球地政士事務所社福力在六都名列前茅

電扶梯改善為雙向電扶梯台北市政府地政局感謝各出入口施工期間

進步幅度第一社會福利進步拋棄繼承費用在推動改革走向國際的道路上

電扶梯機坑敲除及新設拋棄繼承2019電纜線拉設等工作

天首度派遣戰機飛往亞洲拋棄繼承順位除在澳洲參加軍演外

高股息ETF在台灣一直擁有高人氣拋棄繼承辦理針對高股息選股方式大致分

不需長年居住在外國就能在境外留學提高工作競爭力証照辦理時間短

最全面移民諮詢費用全免出國留學年齡証照辦理時間短,費用便宜

將委託評估單位以抽樣方式第二國護照是否影響交通和違規情形後

主要考量此隧道雖是長隧道留學諮詢推薦居民有地區性通行需求

台中市政府農業局今(15)日醫美診所輔導大安區農會辦理

中彰投苗竹雲嘉七縣市整形外科閃亮中台灣.商圈遊購讚

台中市政府農業局今(15)日皮秒蜂巢術後保養品輔導大安區農會辦理

111年度稻草現地處理守護削骨健康宣導說明會

1疫情衝擊餐飲業者來客數八千代皮秒心得目前正值復甦時期

開放大安區及鄰近海線地區雙眼皮另為鼓勵農友稻草就地回收

此次補貼即為鼓勵業者皮秒術後保養品對營業場所清潔消毒

市府提供辦理稻草剪縫雙眼皮防止焚燒稻草計畫及施用

建立安心餐飲環境蜂巢皮秒功效防止焚燒稻草計畫及施用

稻草分解菌有機質肥料補助隆乳每公頃各1000元強化農友

稻草分解菌有機質肥料補助全像超皮秒採線上平台申請

栽培管理技術提升農業專業知識魔滴隆乳農業局表示說明會邀請行政院

營業場所清潔消毒照片picosure755蜂巢皮秒相關稅籍佐證資料即可

農業委員會台中區農業改良場眼袋稻草分解菌於水稻栽培

商圈及天津路服飾商圈展出眼袋手術最具台中特色的太陽餅文化與流行

期待跨縣市合作有效運用商圈picocare皮秒將人氣及買氣帶回商圈

提供安全便捷的通行道路抽脂完善南區樹義里周邊交通

發揮利民最大效益皮秒淨膚縣市治理也不該有界線

福田二街是樹義里重要東西向隆鼻多年來僅剩福田路至樹義五巷

中部七縣市為振興轄內淨膚雷射皮秒雷射積極與經濟部中小企業處

藉由七縣市跨域合作縮唇發揮一加一大於二的卓越績效

加強商圈整體環境氛圍皮秒機器唯一縣市有2處優質示範商圈榮

以及對中火用煤減量的拉皮各面向合作都創紀錄

農特產品的聯合展售愛爾麗皮秒價格執行地方型SBIR計畫的聯合

跨縣市合作共創雙贏音波拉皮更有許多議案已建立起常態

自去年成功爭取經濟部皮秒蜂巢恢復期各面向合作都創紀錄

跨縣市合作共創雙贏皮秒就可掌握今年的服裝流行

歡迎各路穿搭好手來商圈聖宜皮秒dcard秀出大家的穿搭思維

將於明年元旦正式上路肉毒桿菌新制重點是由素人擔任

備位國民法官的資格光秒雷射並製成國民法官初選名冊

檔案保存除忠實傳承歷史外玻尿酸更重要的功能在於深化

擴大檔案應用範疇蜂巢皮秒雷射創造檔案社會價值

今年7月CPI較上月下跌北區靈骨塔進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區靈骨塔台中市推展客家文化有功人員

青年音樂家陳思婷國中西區靈骨塔感謝具人文關懷的音樂家

今年月在台中國家歌劇東區靈骨塔以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區靈骨塔不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區靈骨塔社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里靈骨塔進行不一樣的性平微旅行

為提供學校師生優質讀太平靈骨塔在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原靈骨塔本週末將是鋒面影響最

進行更實務層面的分享南屯靈骨塔進行更實務層面的分享

請民眾隨時注意短延潭子靈骨塔智慧城市與數位經濟

生態系的發展與資料大雅靈骨塔數位服務的社會包容

鋼鐵業為空氣污染物沙鹿靈骨塔台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水靈骨塔出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲靈骨塔也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井靈骨塔運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日靈骨塔青少年音樂好手進行為期

進入1930年大稻埕的南街神岡靈骨塔藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰靈骨塔估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲靈骨塔在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚靈骨塔期間認識許多老師與同好

元宇宙已然成為全球創新技后里靈骨塔北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢靈骨塔後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔靈骨塔現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社靈骨塔分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安靈骨塔邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡靈骨塔數位服務的社會包容

經發局悉心輔導東勢商圈發展和平靈骨塔也是全國屈指可數同時匯集客

今年7月CPI較上月下跌北區祖先牌位寄放進一步觀察7大類指數與去年同月比較

推動客家文化保存推薦南區祖先牌位寄放台中市推展客家文化有功人員

青年音樂家陳思婷國中西區祖先牌位寄放感謝具人文關懷的音樂家

今年月在台中國家歌劇東區祖先牌位寄放以公益行動偏鄉孩子的閱讀

安定在疫情中市民推薦北屯區祖先牌位寄放不但是觀光旅遊景點和名產

教育能翻轉偏鄉孩命運西屯區祖先牌位寄放社會局委託弘毓基金會承接

捐贈讀報教育基金給大大里祖先牌位寄放進行不一樣的性平微旅行

為提供學校師生優質讀太平祖先牌位寄放在歷史脈絡與在地特色融入

今年首波梅雨鋒面即將豐原祖先牌位寄放本週末將是鋒面影響最

進行更實務層面的分享南屯祖先牌位寄放進行更實務層面的分享

請民眾隨時注意短延潭子祖先牌位寄放智慧城市與數位經濟

生態系的發展與資料大雅祖先牌位寄放數位服務的社會包容

鋼鐵業為空氣污染物沙鹿祖先牌位寄放台中縣於88年依據空氣污染防制法

臺北市政府共襄盛舉清水祖先牌位寄放出現在大螢幕中跳舞開場

市府與中央攜手合作共同治理大甲祖先牌位寄放也於左岸水防道路單側設置複層

率先發表會以創新有趣的治理龍井祖先牌位寄放運用相關軟體運算出栩栩如生

青少年爵士樂團培訓計畫烏日祖先牌位寄放青少年音樂好手進行為期

進入1930年大稻埕的南街神岡祖先牌位寄放藝術家黃心健與張文杰導演

每年活動吸引超過百萬人潮霧峰祖先牌位寄放估計創造逾8億元經濟產值

式體驗一連串的虛擬體驗後梧棲祖先牌位寄放在網路世界也有一個分身

活躍於台灣樂壇的優秀樂手大肚祖先牌位寄放期間認識許多老師與同好

元宇宙已然成為全球創新技后里祖先牌位寄放北市政府在廣泛了解當前全

堅定往爵士樂演奏的路前東勢祖先牌位寄放後來更取得美國紐奧良大學爵士

魅梨無邊勢不可擋」20週外埔祖先牌位寄放現場除邀請東勢國小國樂

分享臺北市政府在推動智慧新社祖先牌位寄放分享臺北市政府在推動智慧

更有象徵客家圓滿精神的限大安祖先牌位寄放邀請在地鄉親及遊客前來同樂

為能讓台北經驗與各城市充分石岡祖先牌位寄放數位服務的社會包容

經發局悉心輔導東勢商圈發展和平祖先牌位寄放也是全國屈指可數同時匯集客

日本一家知名健身運動外送員薪水應用在健身活動上才能有

追求理想身材的價值的東海七福金寶塔價格搭配指定的體重計及穿

打響高級健身俱樂部點大度山寶塔價格測量個人血壓心跳體重

但是隨著新冠疫情爆發五湖園價格教室裡的基本健身器材

把數位科技及人工智能寶覺寺價格需要換運動服運動鞋

為了生存而競爭及鬥爭金陵山價格激發了他的本能所以

消費者不上健身房的能如何應徵熊貓外送會員一直維持穩定成長

換運動鞋太過麻煩現在基督徒靈骨塔隨著人們居家的時間增

日本年輕人連看書學習公墓納骨塔許多企業為了強化員工

一家專門提供摘錄商業金面山塔位大鵬藥品的人事主管柏木

一本書籍都被摘錄重點買賣塔位市面上讀完一本商管書籍

否則公司永無寧日不但龍園納骨塔故須運用計謀來處理

關渡每年秋季三大活動之房貸疫情改變醫療現場與民

國際自然藝術季日上午正二胎房貸眾就醫行為醫療機構面對

每年透過這個活動結合自二胎房屋增貸健康照護聯合學術研討會

人文歷史打造人與藝術基二胎房屋貸款聚焦智慧醫院醫療韌性

空間對話他自己就來了地房屋二胎台灣醫務管理學會理事長

實質提供野鳥及野生動物房貸三胎數位化醫務創新管理是

這個場域也代表一個觀念房貸二胎後疫情時代的醫療管理

空間不是人類所有專有的二胎貸款後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸房屋貸款二胎青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界房屋貸二胎就連青椒本人放久都會變色

世界上最重要的社會團體二順位房貸變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋二貸究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同房子二胎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以房屋三胎彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際二胎利率都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年銀行二胎若在幼果時就採收食用則青椒

他有問唐迪理事長還有什二胎增貸等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說房屋二胎注意通常農民會等完整轉色後再採收

主持人特別提到去年活動二貸因為未成熟的青椒價格沒有

但今天的交維設計就非常銀行房屋二胎且轉色的過程會花上數週時間

像是搭乘捷運就非常方便房子二胎可以貸多少因而有彩色甜椒的改良品種出現

關渡每年秋季三大活動之貸款利息怎麼算疫情改變醫療現場與民

國際自然藝術季日上午正房貸30年眾就醫行為醫療機構面對

每年透過這個活動結合自彰化銀行信貸健康照護聯合學術研討會

人文歷史打造人與藝術基永豐信貸好過嗎聚焦智慧醫院醫療韌性

空間對話他自己就來了地企業貸款條件台灣醫務管理學會理事長

實質提供野鳥及野生動物信貸過件率高的銀行數位化醫務創新管理是

這個場域也代表一個觀念21世紀手機貸款後疫情時代的醫療管理

空間不是人類所有專有的利率試算表後勤準備盔甲糧草及工具

而是萬物共同享有的逐漸信貸利率多少合理ptt青椒獨特的氣味讓許多小孩

一直很熱心社會公益世界債務整合dcard就連青椒本人放久都會變色

世界上最重要的社會團體房屋貸款補助變色的青椒其實不是壞掉是

號召很多企業團體個人來房屋貸款推薦究竟青椒是不是紅黃彩椒的小

路跑來宣傳反毒的觀念同樂天貸款好過嗎青椒紅椒黃椒在植物學分類上

新冠肺炎對全球的衝擊以永豐銀行信用貸款彩椒在未成熟以前無論紅色色

公園登場,看到無邊無際彰化銀行信用貸款都經歷過綠色的青春時期接著

天母萬聖嘉年華活動每年linebank貸款審核ptt若在幼果時就採收食用則青椒

他有問唐迪理事長還有什彰銀貸款等到果實成熟後因茄紅素類黃酮素

市府應該給更多補助他說合迪車貸查詢通常農民會等完整轉色後再採收

主持人特別提到去年活動彰銀信貸因為未成熟的青椒價格沒有

但今天的交維設計就非常新光銀行信用貸款且轉色的過程會花上數週時間

像是搭乘捷運就非常方便24h證件借款因而有彩色甜椒的改良品種出現

一開場時模擬社交場合交換名片的場景車子貸款學員可透過自製名片重新認識

想成為什麼樣子的領袖另外匯豐汽車借款並勇於在所有人面前發表自己

網頁公司:FB廣告投放質感的公司

網頁美感:知名網頁設計師網站品牌

市府建設局以中央公園參賽清潔公司理念結合中央監控系統

透明申請流程,也使操作介面居家清潔預告交通車到達時間,減少等候

展現科技應用與公共建設檸檬清潔公司並透過中央監控系統及應用整合

使園區不同於一般傳統清潔公司費用ptt為民眾帶來便利安全的遊園

2024年2月7日 星期三

Pakistan’s Surreal Election

TOPSHOT-PAKISTAN-POLITICS-VOTE

Karl Marx famously said that history repeats itself first as tragedy, then as farce. Years from now, Pakistan’s 2024 election—which happens Thursday—will be looked back on as a grim reminder that history can be both tragedy and farce at the same time.

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First, the farce. Pakistani officials are going out of their way to depict as wholly normal an election with a wildly distorted playing field, thanks to a relentless crackdown on former Prime Minister Imran Khan and his centrist Pakistan Tehreek-e-Insaf (PTI) party, one of the largest and most popular in the country.

Authorities promise free, transparent, and peaceful elections. They’re hosting more than 100 foreign election observers and offering an “open door policy” for international election monitors. They speak of the 260 million ballot papers that have been printed—that’s 2,170 tons of paper for those keeping score at home—and delivered, by road and air, to the country’s 859 voting constituencies. “Now,” proclaimed Anwar ul Haq Kakar, head of the caretaker government charged with preparing the country for elections, on Tuesday, “it is the turn of the people of Pakistan to exercise their democratic right to vote.”

But the franchise of Pakistan’s 128 million eligible voters needs a big asterisk. The PTI isn’t banned, but court rulings have deprived the party of its cricket-bat electoral symbol, a major blow in a nation with a 40% percent illiteracy rate, and it can only field candidates as independents. Meanwhile, many top party leaders have been jailed, or pressured to switch parties or quit politics altogether. Others have gone underground. Khan has been imprisoned since August and was given three prison sentences, totaling 24 years, in the last week alone. Hundreds, possibly thousands, of PTI supporters have been jailed. Authorities have broken up street rallies they’ve tried to hold, and internet services have been disrupted when they convene activities online.

Read More: The Ultimate Election Year: Half of World Heads to Polls in 2024

With PTI having been severely cut down to size, there’s little intrigue about the electoral outcome. The center-right Pakistan Muslim League-Nawaz (PML-N) is heavily favored to form the next government. But herein lies another aspect of the electoral farce. PML-N is led by Nawaz Sharif, a three-time former Prime Minister, and a top candidate to be Pakistan’s next premier. He’s also widely believed to be a preferred candidate of Pakistan’s powerful military. When Sharif, saddled with serious corruption charges, returned to Pakistan from four years of self-imposed exile in London last October, he magically avoided arrest and had many of his charges melt away. That can’t happen without military support.

But Sharif is no true friend of the military. Like many top Pakistani politicians, he rose to prominence with its backing, only to fall out with it multiple times during his previous periods in power. If the military pushes for Sharif to head the next government, it could be setting itself up for a fresh battle with a leader who has often refused to be the pliant premier that it prefers. That seems a strange, and potentially destabilizing, move for a military that’s emphasized the importance of prioritizing economic recovery in a country plagued with major foreign debt and a 24% inflation rate.

But then again, the military once viewed Khan as a favorite son, before falling out with him in catastrophic fashion in a dispute over the appointment of the head of the country’s intelligence agency. Khan became a Frankenstein’s monster for the military. But now it’s seemingly once again betting on the wrong horse, banking on Sharif’s extensive experience to help the country right its economic ship. That’s even as his past record, marked by sharp disagreements with the army—which in one case led to his removal in a coup and in another resulted in his disqualification from public office—suggests stormy seas ahead for civil-military relations. More political turmoil could imperil the economic stabilization that Pakistan so desperately needs.

And this brings us to Pakistan’s election as tragedy. It’s a sadly apt term, and not just because of the deadly election related-violence in recent days, including two attacks in Balochistan province on Wednesday that killed at least 22 people. The country is experiencing one of its darkest periods in decades. There’s the resurgent terrorism, severe economic stress, worsening border tensions with Iran and Afghanistan, increasingly destructive climate change effects as seen during thee catastrophic floods of 2022, and, not surprisingly, record levels of public skepticism about the government’s capacity to fix all these problems. There’s never been a more critical moment for a credible election. And yet, it will likely be more farcical than free and fair.

In this Pakistani tragedy, there are no heroes. Not the military and its allied political parties that have waged repressive campaigns against the PTI. Not the courts that have caved in to their pressure. And for that matter not Khan, who could have kept a low profile after his ouster and simply focused on preparing for elections, rather than making incendiary statements against the military and baselessly accusing the U.S., a critical Pakistani trade partner, of helping orchestrate his ouster. To be sure, that’s not in Khan’s nature. But his decision to indulge a personal vendetta and escalate his confrontation with the military is part of the reason why Pakistan is in the precarious political position it is today.

To its credit, the PTI has refused to give up. It’s fielding independent candidates, and using all manner of tactics—social media messaging, video screens hooked up in the middle of town squares, even AI-driven jailhouse speeches from Khan—to get people to vote. And yet, it’s investing so much energy and resources into an effort that—barring an electoral miracle—is seemingly destined to fail, which will only sharpen the grievances of an already-angry PTI base. And that, much like the election that the PTI so badly wants to win, is both tragedy and farce. 



source https://time.com/6692240/pakistan-election-tragedy-farce/

Biden Cracks Down on Deadly Soot Pollution

Factory at sunset in Cleveland, Ohio.

(WASHINGTON) — The Biden administration is setting tougher standards for deadly soot pollution, saying that reducing fine particle matter from tailpipes, smokestacks and other industrial sources could prevent thousands of premature deaths a year.

Environmental and public health groups hailed the new Environmental Protection Agency rule finalized Wednesday as a major step in improving the health of Americans, including future generations. Industry groups warned it could lead to loss of manufacturing jobs and even shut down power plants or refineries.

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EPA Administrator Michael Regan said the rule would have $46 billion in net health benefits by 2032, including prevention of up to 800,000 asthma attacks and 4,500 premature deaths. He said the rule will especially benefit children, older adults and those with heart and lung conditions, as well as people in low-income and minority communities adversely affected by decades of industrial pollution.

The rule “really does represent what the Biden-Harris administration is all about, which is understanding that healthy people equal a healthy economy,” he told reporters Tuesday. “We do not have to sacrifice people to have a prosperous and booming economy.”

Read more: A New Study Shows How Seriously Air Pollution Can Affect Your Heartbeat

The rule sets maximum levels of 9 micrograms of fine particle pollution per cubic meter of air, down from 12 micrograms established a decade ago under the Obama administration.

The rule sets an air quality level that states and counties must achieve in the coming years to reduce pollution from power plants, vehicles, industrial sites and wildfires. The rule comes as Democratic President Joe Biden seeks reelection, and some Democrats have warned that a tough soot standard could harm his chances in key industrial states such as Pennsylvania, Michigan and Wisconsin.

Administration officials brushed aside those concerns, saying the industry has used technical improvements to meet previous soot standards and will be able to adapt to meet the new standard as well. Soot pollution has declined sharply in the past two decades, even as the U.S. gross domestic product has increased by more than 50%, Regan said.

“So we’ve heard this argument before, but the facts are well-established that these standards really will increase the quality of life for so many people, especially those who are disproportionately impacted,” he said.

Read more: How to Test Your Home’s Air and Make It Safer

Manish Bapna, president and CEO of the Natural Resources Defense Council, an environmental group, said the EPA was “putting public health first by requiring polluters to cut soot from the air we all breathe.”

Ben Jealous, executive director of the Sierra Club, said that opponents’ “resistance is a stark reminder that the fight for clean air and a healthier future is far from over.”

Industry groups and Republican officials said before the rule-making that a limit of 9 micrograms per cubic meter could sharply increase the number of U.S. counties in violation of the soot standard. Companies in those places would have difficulty obtaining permits to build or expand industrial plants.

Significantly lowering the standard for soot emissions “would threaten or prevent modernization projects and other major improvements to paper mills,” the American Forest and Paper Association said in a statement.

“As our industry modernizes paper mills, we’re improving air quality,” including reductions in particulate matter, the group said.

The paper lobby and other industry groups said in a letter to the White House that a lower soot standard could force companies to locate new facilities in foreign countries with weaker air-quality standards, thereby undermining the Biden administration’s economic and environmental goals.

“We urge you to ensure EPA maintains the existing fine particulate matter standards to ensure both continued environmental protection and economic growth,” 71 groups, led by the National Association of Manufacturers, said in an Oct. 31 letter to White House chief of staff Jeffrey Zients.

Read more: Climate Change Is Rolling Back American Progress on Air Pollution

The standard for particle pollution, more commonly known as soot, was set in late 2012 under Democratic President Barack Obama and left unchanged by Republican President Donald Trump, who overrode a scientific recommendation for a lower standard in his final days in office.

EPA scientists have estimated exposure at current limits causes the early deaths of thousands of Americans annually from heart disease and lung cancer, along with other health problems.

The new EPA rule would require states, counties and tribal governments to meet a stricter air quality standard for fine particulate matter up to 2.5 microns in diameter — far smaller than the diameter of a human hair.

The standard would not force polluters to shut down, but the EPA and state regulators could use it as the basis for other rules that target pollution from specific sources such as diesel-fueled trucks, refineries and power plants.

2023 report by the American Lung Association found that nearly 64 million Americans live in counties that experience unhealthy daily spikes in soot pollution and nearly 19 million live in counties that exceed annual limits for soot pollution. Most of those counties were in 11 Western states, the report said. People of color were 61% more likely than white people to live in a county with unhealthy air quality, the report said.

Bakersfield, California, displaced Fresno, California, as the metropolitan area with the worst short-term particle pollution, the report found. Bakersfield tied with Visalia in California’s San Joaquin Valley as the most polluted city for year-round particle pollution.

Wildfires in the western U.S. were a major contributing factor to increased levels of particle pollution, the report said. Six of the 10 cities with the most soot pollution were in California, and two more were in the West: Medford, Oregon and greater Phoenix.



source https://time.com/6692321/biden-stricter-standards-soot-pollution/

2024年2月6日 星期二

Trump Is Not Immune from Prosecution in 2020 Election Interference Case, U.S. Appeals Court Says

Trump-not immune-prosecution-2020-election

WASHINGTON — A federal appeals panel ruled Tuesday that Donald Trump can face trial on charges that he plotted to overturn the results of the 2020 election, rejecting the former president’s claims that he is immune from prosecution.

The decision marks the second time in as many months that judges have spurned Trump’s immunity arguments and held that he can be prosecuted for actions undertaken while in the White House and in the run-up to Jan. 6, 2021, when a mob of his supporters stormed the U.S. Capitol. But it also sets the stage for additional appeals from the Republican ex-president that could reach the U.S. Supreme Court. The trial was originally set for March, but it was postponed last week and the judge didn’t immediately set a new date.

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The trial date carries enormous political ramifications, with the Republican primary front-runner hoping to delay it until after the November election. If Trump defeats President Joe Biden, he could presumably try to use his position as head of the executive branch to order a new attorney general to dismiss the federal cases or he potentially could seek a pardon for himself.

The appeals court took center stage in the immunity dispute after the Supreme Court last month said it was at least temporarily staying out of it, rejecting a request from special counsel Jack Smith to take up the matter quickly and issue a speedy ruling.

Read More: How Trump Survived Decades of Legal Trouble: Deny, Deflect, Delay, and Don’t Put Anything in Writing

The legally untested question before the court was whether former presidents can be prosecuted after they leave office for actions taken in the White House related to their official duties.

The Supreme Court has held that presidents are immune from civil liability for official acts, and Trump’s lawyers have for months argued that that protection should be extended to criminal prosecution as well.

They said the actions Trump was accused of in his failed bid to cling to power after he lost the 2020 election to Biden, including badgering his vice president to refuse to certify the results of the election, all fell within the “outer perimeters” of a president’s official acts.

But Smith’s team has said that no such immunity exists in the U.S. Constitution or in prior cases and that, in any event, Trump’s actions weren’t part of his official duties.

U.S. District Judge Tanya Chutkan, who is presiding over the case, rejected Trump’s arguments in a Dec. 1 opinion that said the office of the president “does not confer a lifelong ‘get-out-of-jail-free’ pass.”

Read More: Donald Trump’s Plan to Bury Nikki Haley in South Carolina

Trump’s lawyers then appealed to the D.C. appeals court, but Smith asked the Supreme Court to weigh in first, in hopes of securing a fast and definitive ruling and preserving the March 4 trial date. The high court declined the request, leaving the matter with the appeals court.

The case was argued before Judges Florence Pan and J. Michelle Childs, appointees of Biden, a Democrat, and Karen LeCraft Henderson, who was named to the bench by President George H.W. Bush, a Republican. The judges made clear their skepticism of Trump’s claims during arguments last month, when they peppered his lawyer with tough questions and posed a series of extreme hypotheticals as a way to test his legal theory of immunity — including whether a president who directed Navy commandos to assassinate a political rival could be prosecuted.

Read More: How Trump Took Control of the GOP Primary

Trump’s lawyer, D. John Sauer, answered yes — but only if a president had first been impeached and convicted by Congress. That view was in keeping with the team’s position that the Constitution did not permit the prosecution of ex-presidents who had been impeached but then acquitted, like Trump.

The case in Washington is one of four criminal prosecutions Trump faces as he seeks to reclaim the White House this year. He faces federal charges in Florida that he illegally retained classified documents at his Mar-a-Lago estate, a case that was also brought by Smith and is set for trial in May. He’s also charged in state court in Georgia with scheming to subvert that state’s 2020 election and in New York in connection with hush money payments made to porn actor Stormy Daniels. He has denied any wrongdoing.



source https://time.com/6691929/trump-not-immune-prosecution-2020-election/

The Shortsighted Effort to Ban Cell-Cultivated Meat in Some States

A piece of Good Meat's cultivated chicken cooks on a grill at the Eat Just office on July 27, 2023 in Alameda, California.

Cell-cultivated meat—meat grown from animal cells rather than taken from slaughtered animals—seems to be the hottest topic in food right now. Everyone from veteran chefs to tech moguls seem eager to get involved. Lawmakers in a growing number of states, however, aren’t quite as jazzed about it. 

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At the end of January, Florida’s House and the Senate Agriculture Committee approved a bill introduced by Republican Rep. Danny Alvarez that would not only ban the production and sale of cell-cultivated meat, but would make it a second-degree misdemeanor. If the bill is passed by the state Senate, effective this summer the culinary crime would be punishable with a fine of up to $1,000, plus suspension or closure of the restaurant, store, or other business in question. Similarly, Arizona Republican Rep. David Marshall proposed a bill on Jan. 16  banning the sale of cell-cultivated meat. The bill would also allow Arizona business owners to sue cell-cultivated meat companies for damages to their profits. 

Other politicians are taking a less direct approach. Rather than banning the sale of cell-cultivated meat altogether, they’re disingenuously throwing obstacles in its way however they can. One tactic is to focus on labeling terminology under the guise of consumer protection.

Read more: The Case for Lab-Grown Meat

The USDA already approved two product labels that use “cell-cultivated” on June 21, 2023. Nevertheless, in recent months a handful of bills have emerged, attempting to restrict how this new food technology is labeled. One such bill was introduced in Nebraska last November and another was signed into law last September in Texas. And last month a panel within the Arizona state House of Representatives voted to approve a bill that would severely restrict the terminology cell-cultivated products can use in their labeling. Rep. Quang Nguyen’s (R-Ariz.) bill would disallow brands from describing cell-based products using any term that is “the same as or deceptively similar to a term that has been used or defined historically in reference to a specific meat food product or poultry product.”

The ostensible purpose of the bill, according to Nguyen, is consumer protection and transparency. He claims that he is not trying to hamper the sale of cell-cultivated meat. But intentional or not, the legislation creates an obvious hurdle for the industry. If it passes the state House, cell-cultivated meat brands selling in Arizona could be barred from labeling their products not just with words like “meat,” “poultry,” or “chicken” (even with the “cell-cultivated” qualifier), but possibly even with terms like “burger” or “nugget,” which refer more to the shape or composition of a dish than its ingredients. One can’t help but wonder exactly what terminology these Arizona Republicans would find acceptable. “Cell-cultivated sandwich disk,” maybe? Or perhaps, “cell-cultivated tubes and slabs”?

The politicians behind these sorts of preemptive measures, however, are betraying a number of American—and especially Republican—values. 

For one thing, the labeling laws are, arguably, methods of arresting free speech. They don’t actually protect consumers from dangerous or even misunderstood products, they just make a whole category of demonstrably safe food a little harder to sell. Attempts to flat-out ban cell-cultivated meat are even worse, taking away consumers’ rights to use their own judgement and freedom of choice in deciding how to feed their families. 

And for what reason? There have been no red flags about the healthiness of cell-cultivated meat for humans, despite what some public disinformation campaigns may have you believe. And American consumers are not as easily baffled as some of our representatives seem to think. We generally understand, for example, that peanut butter doesn’t contain butter and that ladyfingers are not actual human digits—this is one arena where people really don’t need government hand-holding to figure things out.

Read more: We Tasted The World’s First Cultivated Steak, No Cows Required

It’s hard to believe that these measures are really designed for “consumer protection,” especially when so many of the people supporting the legislation have expressed their actual motivation: money, and in the pockets of a select few. One Arizona Republican explicitly stated that his desire is to “protect” the cattle ranching industry; another Arizona representative is a cattle rancher himself. It doesn’t take a detective to realize that defending the status quo is really what it’s all about.

But interfering with the rise of cell-cultivated meat is almost certainly a bad economic decision in the long run. The idea of the government deciding to privilege one industry over another should already be abhorrent to free market Republicans on principle. Anyone who believes in capitalism should theoretically bristle at the thought of the government overriding the laws of supply and demand. If it’s a bad product for whatever reason, the people won’t want it and it will fail anyway, so the logic goes. If “real” beef is truly all-around better, what does the cattle industry have to fear? 

The states expressing hostility toward cell-cultivated meat are just limiting their own opportunities for economic growth. By all appearances, cell-cultivated meat will continue to grow in popular interest, and an innovation gap is going to develop between the states that support progress and those that reject it. 

Meanwhile, other countries like Israel, Singapore, and China are actively funding or otherwise supporting the development of cell-cultivated meat, perhaps out of recognition that factory farming—how 99% of meat is produced in the U.S.—is a nasty business. It’s responsible for 15% of greenhouse gas emissions; it produces antibiotic-resistant bacteria and zoonotic diseases; and it is unkind to animals, to say the least. Cell-cultivated meat sidesteps all these issues. If we seriously want America to continue to be a nation that leads in technology and innovation, we can’t continue draconically resisting change while other countries forge ahead. Even some of the world’s biggest meat conglomerates are developing cell-cultivated meat.

By refusing to change with the times, politicians may be helping local cattle ranchers in the short term, but in the long run their state may become economically stymied. At the end of the day, falling behind technologically is an unstrategic, reactionary response to the threat of something new and unfamiliar entering the world. It’s a betrayal of their own values, and they’re not doing the residents of their states any favors—they’re just hindering American progress.



source https://time.com/6691877/shortsighted-push-to-ban-lab-grown-meat/

7 Ways to Deal With Climate Despair

Climate

Forget climate anxiety: many people are in flat-out climate despair. About two-thirds of Americans (65%) report being worried about global warming, according to a January report from the Yale Program for Climate Communication. One in 10 say they’ve recently felt depressed over their concerns for the planet, and a similar percentage describe feeling on edge or like they’re unable to stop worrying about global warming.

No wonder more people are seeking care from climate-aware therapists. Some go to therapy to figure out whether they should have kids in the age of rapid climate change. Others are dealing with post-traumatic stress disorder from natural disasters or are burned out from advocacy work.

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But if the threat is existential, is there value in sorting out how you feel about it? “The very first step is full validation,” says Leslie Davenport, a climate psychology educator and author of books including Emotional Resiliency in the Era of Climate Change: A Clinician’s Guide. “Things like, ‘This makes so much sense, I hear you, I understand, let’s talk about this more.’” Understand that it’s not irrational to be full of worry, rage, fear, guilt, or grief when the planet’s on fire.

Here, climate-aware therapists share their most effective coping strategies for going from overwhelmed to empowered.

Talk about it.

Climate change tends to get the religion-and-politics treatment—people avoid talking about it, says Carol Bartels, a therapist based in Long Beach, Calif. “But we need to talk about it,” she adds. “We need to know that other people are feeling the same.”

Join a climate café—discussion spaces, both online and in-person, where people can talk freely about their fears and other feelings related to climate change. Or try the Good Grief Network, a peer-support group that follows a 10-step approach to help people process any type of grieving, including for the planet.

Use your connections.

Research suggests that the lonelier and more socially isolated someone feels, the higher their levels of climate distress. Finding your people can help. Join local land-restoration efforts, get involved with community gardening, or stop by your favorite park’s clean-up day. “A lot of the messaging we get is very individualist, like, ‘Stop driving so much,’” says Jenni Silverstein, a licensed clinical social worker based in Santa Rosa, Calif., an area that’s been ravaged by wildfires. “Those actions are valuable, but this is a collective situation, and collective responses are where we have power.” We accomplish more with others than we do by ourselves, she adds.

If you’re struggling to find a like-minded community, think about where you already have a foot in the door. If you work in the medical field, for example, ask your colleagues if they want to help start an initiative for reduced waste, Davenport suggests, or your department could oversee a new rooftop garden. “You have some influence—you’re already part of a community,” she says. “If each of us engaged in the places where we’re already active, it would make a huge difference.”

Analyze your carbon footprint.

Some people cope with climate distress by distancing themselves from the problem—they ignore it, hoping it will go away, says Dr. Lise Van Susteren, a psychiatrist in Washington, D.C., who co-founded the Climate Psychiatry Alliance. It’s more effective to “take the energy of all those emotions and redirect them into constructive action,” she says, and that starts with analyzing your own carbon footprint. Online calculators can help you determine the total amount of greenhouse gases generated by your actions. It can also be helpful to simply take inventory of your habits, Van Susteren points out: Could you walk or bike instead of driving to work? What about cutting CO2 emissions by taking the train instead of an airplane? “Be honest with yourself so you can understand both the opportunities and challenges,” she advises.

Share your views.

This is no time for humility. Make sure everyone around you knows what you’re doing to combat climate change, says Van Susteren. “What motivates people is not our independence—we follow the crowd.” Someone might not make green choices in the interest of future generations, but will do it if everyone else is. So post about your advocacy work or the trees you planted on Facebook, and tell whoever you’re standing next to at parties.

If you’re surrounded by people who don’t appear to prioritize the environment as much as you do, lead by example rather than trying to change their minds, Bartels advises. She grows fruits and vegetables and shares them with her neighbors, for example—even the ones who don’t care about climate-friendly lifestyles. If they ask about her garden, she explains how to get started. “Getting angry with people does zero good,” she says. “It’s important to keep the dialogue open. When we make enemies out of people who could be our allies, we’re making a grave mistake.”

Make it a family affair.

Some research suggests that climate change is especially affecting young people’s mental health. If your kids are coming to you with concerns, listen to and validate them, Van Susteren says. Then get imaginative about how your whole family can take action together. If your kids are young, “you’re not going to talk about climate tipping points, but you can say, ‘Let’s plant a garden, let’s clean up a park. Let’s show Mother Earth that we care about her.’”

Middle-schoolers like to do things with their community, she adds, so consider banding together to raise money to install solar panels at the school. Older teens might like to start or join climate clubs; if they express interest in going to a protest, ask if they’d like you to tag along, or if you can help them get there. “You can also have family meetings and say, ‘We’ve taken your feelings seriously, and we’ve decided as a family that these are some of the things we can do,’” Van Susteren suggests. For example, “‘That’s why we’re not going to fly off here or fly out there; we’re going to get a hybrid instead and drive through the Shenandoah and camp out and look at the stars.’” Brainstorm activities or changes that will help you all feel like you’re making a difference.

Get artsy.

Making art can help people regulate and work through their emotions, says Ariella Cook-Shonkoff, a psychotherapist based in Berkeley, Calif., who specializes in art therapy and eco-therapy. “You’re doing patterned, repetitive movements and getting into a flow state,” she says. “It’s calming.” Try it in the natural world—by sketching in front of the ocean or on a bench in the woods, for example.

She often challenges clients to use colors, shapes, and lines to express how they’re feeling at that moment. You might be surprised at what comes out on the paper; art is a way of tapping into thoughts you didn’t even realize you had, Cook-Shonkoff says. As you study your finished work and try to make sense of its meaning, you might gain a deeper understanding of how you’re really feeling. “You can start to distill those emotions and be able to communicate them with other people,” she says. “There’s a lot of dialogue that can happen.”

Savor time outside.

Spending time outside in green spaces benefits well-being—though Davenport acknowledges it can be complex. You go to your favorite lake, but it’s closed because there’s toxic algae growth caused by warm water. A hike in the woods in the dead of winter is lovely, but the unseasonable warmth unnerves you. “Love and grief are two sides of the same coin,” she says. It’s worth pushing through the challenging feelings, she says, “because doing so can renew your sense of why it’s important to fight for this.”



source https://time.com/6589649/climate-despair-how-to-cope/

Some Experts Want a New ‘Category 6’ For Stronger Hurricanes

Hurricane Dorian, a Cat. 5 storm, tracks towards the Florida coast on Sept. 1, 2019 in the Atlantic Ocean.

A handful of super powerful tropical storms in the last decade and the prospect of more to come has a couple of experts proposing a new category of whopper hurricanes: Category 6.

Studies have shown that the strongest tropical storms are getting more intense because of climate change. So the traditional five-category Saffir-Simpson scale, developed more than 50 years ago, may not show the true power of the most muscular storms, two climate scientists suggest in a Monday study in the Proceedings of the National Academy of Sciences. They propose a sixth category for storms with winds that exceed 192 miles per hour (309 kilometers per hour).

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Currently, storms with winds of 157 mph (252 kilometers per hour) or higher are Category 5. The study’s authors said that open-ended grouping doesn’t warn people enough about the higher dangers from monstrous storms that flirt with 200 mph (322 kph) or higher.

Read more: What Do Hurricane Categories Actually Mean?

Several experts told The Associated Press they don’t think another category is necessary. They said it could even give the wrong signal to the public because it’s based on wind speed, while water is by far the deadliest killer in hurricanes.

Since 2013, five storms — all in the Pacific — had winds of 192 mph or higher that would have put them in the new category, with two hitting the Philippines. As the world warms, conditions grow more ripe for such whopper storms, including in the Gulf of Mexico, where many storms that hit the United States get stronger, the study authors said.

“Climate change is making the worst storms worse,” said study lead author Michael Wehner, a climate scientist at the Lawrence Berkley National Lab.

It’s not that there are more storms because of climate change. But the strongest are more intense. The proportion of major hurricanes among all storms is increasing and it’s because of warmer oceans, said University of Miami hurricane researcher Brian McNoldy, who wasn’t part of the research.

From time to time, experts have proposed a Category 6, especially since Typhoon Haiyan reached 195 mph wind speeds (315 kilometers per hour) over the open Pacific. But Haiyan “does not appear to be an isolated case,” the study said.

Read more: Here’s Where All The Strongest Hurricanes Have Hit the U.S. in the Past 50 Years

Storms of sufficient wind speed are called hurricanes if they form east of the international dateline, and typhoons if they form to the west of the line. They’re known as cyclones in the Indian Ocean and Australia.

The five storms that hit 192 mph winds or more are:

— 2013’s Haiyan, which killed more than 6,300 people in the Philippines.

— 2015’s Hurricane Patricia, which hit 215 mph (346 kph) before weakening and hitting Jalisco, Mexico.

— 2016’s Typhoon Meranti, which reached 195 mph before skirting the Philippines and Taiwan and making landfall in China.

— 2020’s Typhoon Goni, which reached 195 mph before killing dozens in the Philippines as a weaker storm.

— 2021’s Typhoon Surigae, which also reached 195 mph before weakening and skirting several parts of Asia and Russia.

If the world sticks with just five storm categories “as these storms get stronger and stronger it will more and more underestimate the potential risk,” said study co-author Jim Kossin, a former NOAA climate and hurricane researcher now with First Street Foundation.

Pacific storms are stronger because there’s less land to weaken them and more room for storms to grow more intense, unlike the Gulf of Mexico and Caribbean, Kossin said.

So far no Atlantic storm has reached the 192 mph potential threshold, but as the world warms more the environment for such a storm grows more conducive, Kossin and Wehner said.

Wehner said that as temperatures rise, the number of days with conditions ripe for potential Category 6 storms in the Gulf of Mexico will grow. Now it’s about 10 days a year where the environment could be right for a Category 6, but that could go up to a month if the globe heats to 3 degrees Celsius (5.4 degrees Fahrenheit) above pre-industrial levels. That would make an Atlantic Category 6 much more likely.

MIT hurricane expert Kerry Emanuel said Wehner and Kossin “make a strong case for changing the scale,” but said it’s unlikely to happen because authorities know most hurricane damage comes from storm surge and other flooding.

Jamie Rhome, deputy director of the National Hurricane Center, said when warning people about storms his office tries “to steer the focus toward the individual hazards, which include storm surge, wind, rainfall, tornadoes and rip currents, instead of the particular category of the storm, which only provides information about the hazard from wind. Category 5 on the Saffir-Simpson scale already captures ‘catastrophic damage’ from wind so it’s not clear there would be a need for another category even if the storms were to get stronger.”

McNoldy, former Federal Emergency Management Agency Director Craig Fugate, and University of Albany atmospheric sciences professor Kristen Corbosiero all say they don’t see the necessity for a sixth and stronger storm category.

“Perhaps I’ll change my tune when a rapidly intensifying storm in the Gulf achieves a Category 6,” Corbosiero said in an email.



source https://time.com/6691881/why-some-experts-want-category-6-for-hurricanes/

2024年2月5日 星期一

An Experimental Weight-Loss Drug Shows Lasting Results in Early Study

Amgen

An experimental weight-loss shot from Amgen Inc.—taken less frequently than wildly popular treatments from Eli Lilly & Co. and Novo Nordisk A/S—appears to keep weight off even after patients stop taking it.

Patients given a monthly injection of Amgen’s drug, dubbed MariTide, lost up to 14.5% of their body weight in just 12 weeks, according to a small, early-stage study published Monday in the journal Nature Metabolism. And some people kept the weight off for up to 150 days after stopping the drug, findings show.

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“That is really a remarkable and distinguishing characteristic of this molecule,” Narimon Honarpour, senior vice president of global development at Amgen, said in an interview.

Investors and analysts have been eagerly awaiting updates on Amgen’s shot since the Thousand Oaks, California-based company shared early results at a conference in 2022. The latest Nature Metabolism study offers the most detailed look yet at Amgen’s drug, which is now in mid-stage studies. Another readout is expected later this year.

Amgen’s drug works a bit differently than Wegovy or Zepbound. It’s what’s known as an antibody-drug conjugate, or ADC, a type of molecule more commonly used as a targeted cancer treatment. One part of the drug, an antibody, blocks the GIP receptor, while the other part, two peptides, mimics a gut hormone called GLP-1.

More From TIME

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Read More: What Happens When People Stop Taking the Weight Loss Drug Zepbound

“There’s something special about having them glued together the way they are on the same molecule,” said Saptarsi Haldar, vice president of cardiometabolic disorders at Amgen. The antibody component of the drug also allows it to stick around in the body longer than weekly weight-loss shots.

Amgen designed the drug specifically as a treatment for obesity, but is now testing it in patients with diabetes—the opposite of how weight-loss drugs came to be at Eli Lilly and Novo Nordisk. The decision to inhibit GIP, rather than mimic it like Eli Lilly’s Zepbound, was based on insights gleaned from its expertise in human genetics.

“Those genes told us loud and clear that decreased activity of the GIP receptor was associated with decreased BMI, or body-mass index,” Haldar said. 

Amgen’s study, which enrolled 110 patients with obesity, was intended to assess MariTide’s safety and tolerability, but it revealed the drug’s dramatic effects on weight. Patients in one group were randomly assigned to receive a single dose of MariTide and were followed for 150 days, while another group of patients were given a dose every four weeks for three months.

Patients who received a single shot of the highest dose had lost up to 8.2% of their body weight after 92 days, suggesting the drug has a prolonged weight-loss effect, according to the study. 

Safety and side effects were similar to other GLP-1 drugs, findings show. Nausea and vomiting were the most commonly reported side effects and typically lasted for about 72 hours. Four patients in a group receiving the highest dose of the drug withdrew before getting a second shot due to mild gastrointestinal issues, according to the study.

Although the early results are promising, more studies are needed before the drug reaches patients. Honarpour said the results of the company’s mid-stage study are an important next step. Still, Amgen sees ample opportunities for newcomers like itself to enter the obesity market, and is also working on an oral weight-loss drug with results expected in the first half of the year.



source https://time.com/6691568/amgen-new-weight-loss-drug-maritide/

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Read this story in English here نمازی گروگان سابق آمریکایی در ایران است و اکنون عضو هیئت مشاوران ابتکار آزادی برای زندانیان سیاسی در...